Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 436-710-6 | CAS number: 756-13-8
Skin sensitisation (in vivo): Not sensitisting (OECD406/GLP; Buehler test)
Maximum concentration not causing irritating effects in preliminary test: 100 %
Signs of irritation during induction: No signs of irritation observed.
Evidence of sensitisation of each challenge concentration: 0%
Other observations: None.
There is no in vitro skin sensitisation data available. There is one in vivo skin sensitisation study in guinea pigs available.
In a dermal sensitization study (OECD406/GLP) with 1,1,1,2,2,4,5,5,5-nonafluoro-4-(trifluoromethyl )-3-pentanone, Dunkin-Hartley guinea pigs were tested in a Buehler assay. A maximisation study could not be performed due to the physico-chemical properties of the substance. No proper vehicle could be found, since in the vehicle, the test substance was not homogenous. Also, during a Preliminary Irritation Test, injection with the undiluted test substance resulted in necrosis (diameter of 5 mm). A 100% test substance concentration did therefore not comply with the selection criteria for dose level selection for the main study of the Guinea Pig Maximization Test. The Buehler Test is the preferred test after the Guinea Pig Maximization Test. No irritation was observed after epidermal application of the undiluted test substance (100%). The evaluation of skin reactions after challenge was carried out at 24 and 48 hrs. There were no signs of irritation observed during induction. There was no evidence of sensitisation during challenge in test (0/20) or control (0/10) animals. There were no other observations. The substance was not sensitising.
The results from this study are acceptable to use in the human health risk assessment.
Based on the available information in the dossier, the substance 1,1,1,2,2,4,5,5,5-nonafluoro-4-(trifluoromethyl )-3-pentanone (CAS No. 756-13-8) does not need to be classified for skin sensitisation when the criteria outlined in Annex I of 1272/2008/EC and Annex I of 286/2011/EC are applied.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again