Registration Dossier
Registration Dossier
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EC number: 436-710-6 | CAS number: 756-13-8
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: The study was designed to be in compliance with EEC (Annex II, point 5.2.3), OECD 403, US EPA and J-MAFF test guidelines for inhalation studies.
- GLP compliance:
- yes
- Limit test:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 436-710-6
- EC Name:
- -
- Cas Number:
- 756-13-8
- Molecular formula:
- C6F12O
- IUPAC Name:
- 1,1,1,2,2,4,5,5,5-nonafluoro-4-(trifluoromethyl)pentan-3-one
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Albino Sprague-Dawley
Administration / exposure
- Type of inhalation exposure:
- other: Snout only
- Vehicle:
- other: None
- Duration of exposure:
- 4 h
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 1 275 mg/L air
- Exp. duration:
- 4 h
- Mortality:
- Male: CA 1275 mg/L; Number of animals: 5; Number of deaths: 0
Male: 0 mg/L; Number of animals: 5; Number of deaths: 0
Female: CA 1275 mg/L; Number of animals: 5; Number of deaths: 0
Female: 0 mg/L; Number of animals: 5; Number of deaths: 0 - Clinical signs:
- other: Signs of toxicity related to dose levels: Exagerrated breathing was evident in test rats from 30 minutes into exposure, persisting for at least 2 hours post exposure.
- Gross pathology:
- Effects on organs:
There were no treatment related findings.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified; Criteria used for interpretation of results: EU
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