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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed
Report date:
2002

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: EC Directive 92/69, B.3 OECD 402, 1987
GLP compliance:
yes
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
436-710-6
EC Name:
-
Cas Number:
756-13-8
Molecular formula:
C6F12O
IUPAC Name:
1,1,1,2,2,4,5,5,5-nonafluoro-4-(trifluoromethyl)pentan-3-one

Test animals

Species:
rat
Strain:
other: Wistar Crl:(WI)BR

Administration / exposure

Type of coverage:
semiocclusive
Vehicle:
unchanged (no vehicle)
Duration of exposure:
24 h

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Clinical signs:
other: Signs of toxicity related to dose levels: Lethargy, hunched posture, piloerection, chromodacryorrhoea and/or diarrhoea were noted in the majority of animals. The animals had recovered from the symptoms by day 4, with the exception of one female, which sho
Gross pathology:
Effects on organs:
No abnormalities were found at macroscopic post mortem examination of the animals.
Other findings:
Signs of toxicity (local):
Erythema and/or scales were seen in the treated skin-area and/or the right flank of the animals during the observation period.

Applicant's summary and conclusion

Interpretation of results:
other: Not classified ; Criteria used for interpretation of results: EU