Registration Dossier

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed
Report Date:
2002

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: EC Directive 92/69, B.3 OECD 402, 1987
GLP compliance:
yes
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
other: Wistar Crl:(WI)BR

Administration / exposure

Type of coverage:
semiocclusive
Vehicle:
unchanged (no vehicle)
Duration of exposure:
24 h

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Clinical signs:
Signs of toxicity related to dose levels: Lethargy, hunched posture, piloerection, chromodacryorrhoea and/or diarrhoea were noted in the majority of animals. The animals had recovered from the symptoms by day 4, with the exception of one female, which showed chromodacryorrhoea between days 13 and 15.
Gross pathology:
Effects on organs:
No abnormalities were found at macroscopic post mortem examination of the animals.
Other findings:
Signs of toxicity (local):
Erythema and/or scales were seen in the treated skin-area and/or the right flank of the animals during the observation period.

Applicant's summary and conclusion

Interpretation of results:
other: Not classified ; Criteria used for interpretation of results: EU