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EC number: 202-208-9 | CAS number: 93-00-5
Table No. I
Summary of Clinical Signs of Toxicity and Mortality
Test System : Sprague Dawley Rat
Sex : Female
Group I :
Total Number of
Period of signs in days
From - to
No clinical signs observed
Day 0 - Day 14
Group I :
Group II :
Mean Body Weight and Percent Body Weight Gain (g)
Group I :
(mg/kg body weight)
Before Fasting Body weight
Body weight Day 7
% body weight gain
Body weight Day 14
day 7- 14
day 0- 14
Summary of Gross Pathological Findings
Gross Pathological Findings
1 - 3
No abnormality detected
4 - 6
7 - 9
Group II :
10 - 12
TS = Terminal Sacrifice
The reported study was designed and conducted to determine the acute oral toxicity profile of the given test chemical in Sprague Dawley rats.
Initially, three female animals were treated at the dose level of 300 mg/kg body weight of the test item (Step - I). Administration of the test item at 300 mg/kg did not result in any signs of toxicity and mortality at 24 hours after the dosing. As no mortality was observed at 24 hours after the dosing, three female animals were added to the study and treated with the same dose of 300 mg/kg of the test item (Step - II). Administration of the test item at 300 mg/kg did not result in any signs of toxicity and mortality after the dosing.
No mortality was observed at 300 mg/kg dose group, hence additional three female animals were treated with the higher dose of 2000 mg/kg of the test item (Step - I). Administration of the test item at 2000 mg/kg did not result in any signs of toxicity and mortality after the dosing. As no mortality were observed at 24 hours after the dosing, additional three female animals were treated with the higher dose of 2000 mg/kg of the test item (Step - II). Administration of the test item at 2000 mg/kg did not result in any signs of toxicity and mortality after the dosing.
Gross pathological examination did not reveal any abnormalities in animals from 300 mg/kg and 2000 mg/kg dose groups.
Under the condition of the study, the acute oral LD50 value of the given test chemical was considered to be >2000 mg/kg body weight. Thus, it was concluded that the acute toxicity study of the given test chemical, when administered via oral route in Sprague Dawley rats falls into the “Category Not classified” criteria of CLP.
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