Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
19 February 2015 - 28 May 2015
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: The study is considered to be a reliability 1 as it has been conducted according to EC A.8 and OECD TG 117 and in compliance with GLP.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2015
Report Date:
2015

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient)
Version / remarks:
(2008)
Deviations:
no
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Version / remarks:
(2004)
Deviations:
no
Qualifier:
according to
Guideline:
EPA OPPTS 830.7570 (Partition Coefficient, n-octanol / H2O, Estimation by Liquid Chromatography)
Version / remarks:
(1996)
Deviations:
no
GLP compliance:
yes
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: liquid
Details on test material:
- Name of test material in report: IFF 09-0035
- Physical state: Clear liquid
- Storage condition of test material: At room temperature protected from light

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
5.6
Remarks on result:
other: Pow: 3.8E05. Non-buffered mobile phase
Details on results:
- In the chromatogram of the test solution, one test substance peak was observed
- In the chromatogram of the blank, no test substance related peak was observed

Any other information on results incl. tables

Substance

Retention time #1

[minutes]

Retention time #2

[minutes]

Average retention time

[minutes]

Log Pow

Pow

Area %

Formamide

1.128

1.117

1.123

 

 

 

Toluene

3.018

3.021

3.020

2.7

1,4-Dichlorobenzene

3.918

3.924

3.921

3.0

Biphenyl

5.252

5.262

5.257

4.0

Dibenzyl

7.914

7.937

7.926

4.8

Triphenylamine

12.533

12.575

12.554

5.7

4,4’-DDT

16.800

16.865

16.833

6.5

Test substance

11.173

11.182

11.178

5.6

3.8 x 105

100

 

Remark: log Pow values for the reference substances are according to OECD 117.

Applicant's summary and conclusion

Conclusions:
The partition coefficient of IFF 09-0035 has been determined as log Pow 5.6 according to EC A.8 and OECD TG 117 (HPLC method) in compliance with GLP.
Executive summary:

Using the HPLC method in accordance with EC A.8 and OECD TG 117, the log Pow for the substance was determined to be 5.6.