Registration Dossier

Administrative data

Endpoint:
boiling point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
19 February 2015 - 28 May 2015
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: The study is considered to be a reliability 1 as it has been conducted according to EC A.2 and OECD TG 103 and in compliance with GLP.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2015
Report Date:
2015

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
OECD Guideline 103 (Boiling point/boiling range)
Version / remarks:
(1995)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.2 (Boiling Temperature)
Version / remarks:
(2008)
Deviations:
no
Qualifier:
according to
Guideline:
EPA OPPTS 830.7220 (Boiling Point / Boiling Range)
Version / remarks:
(1996)
Deviations:
no
GLP compliance:
yes
Type of method:
differential scanning calorimetry
Remarks:
(DSC)

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: liquid
Details on test material:
- Name of test material in report: IFF 09-0035
- Physical state: Clear liquid
- Storage condition of test material: At room temperature protected from light

Results and discussion

Boiling point
Boiling pt.:
224 °C
Atm. press.:
1 041 - 1 043 hPa
Remarks on result:
other: Boiling point: 497 K

Any other information on results incl. tables

PRELIMINARY TEST WITH TGA

From 150°C upwards the weight of the sample decreased significantly. At 222°C, the sample weight had decreased by 25%. After the experiment, it was observed that the test substance had evaporated from the sample container.

DSC EXPERIMENTS

- Experiment 1: During cooling to -90°C no crystallization of the substance was observed. During heating, an endothermic peak between 150°C and 250°C was observed. The extrapolated onset temperature of the peak was 224.18°C. The effect was most likely obtained due to boiling of the test substance. After the experiment it was observed that the test substance had evaporated from the sample container.

- Experiment 2: To investigate the boiling peak, a closed sample container was applied in the Experiment 2. An exothermic peak between 175°C and 225°C was observed. The reason for this effect is unknown. The extrapolated onset temperature of the boiling peak was 284.75°C. The endothermic peak shifted to higher temperature. It demonstrated that boiling of the test substance was the reason for the endothermic effect. Since the experiment was performed under higher pressure, the extrapolated onset is not used for calculation of the boiling temperature. After the experiment it was observed that the test substance had evaporated from the sample container.

- Experiment 3: Experiment 3 was performed as a duplicate of the heating part of Experiment 1, to determine the boiling temperature of the test substance. The extrapolated onset of the boiling peak was 223.97°C. After the experiment, it was observed that the test substance had evaporated from the sample container.

The boiling temperature was determined as the average boiling temperature obtained from Experiment 1 (224.18°C) and Experiment 3 (223.97°C).

Applicant's summary and conclusion

Conclusions:
The boiling point of IFF 09-0035 was determined using an reliable GLP study according to the OECD TG 103 using the DSC method. The boiling point of the substance is 224°C at atmospheric pressure (1042 hPa).
Executive summary:
The boiling point of IFF 09-0035 was determined to be 224°C at atmospheric pressure (1042 hPa) according to OECD TG 103 using the DSC method.