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Physical & Chemical properties

Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
14-16 May 2014
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Remarks:
The Department of Health of the Government of the United Kingdom
Type of method:
effusion method: vapour pressure balance
Key result
Test no.:
#1
Temp.:
25 °C
Vapour pressure:
28 Pa

Results of 7 runs are given in tables below:

Run 1

Temperature [°C]

Reciprocal temperature [K-1]

Mass difference [µg]

Log VP

-15

0.003873717

212.80

-0.529558755

-14

0.003858769

249.99

-0.459607742

-13

0.003843936

277.62

-0.414079629

-12

0.003829217

317.70

-0.355513164

-11

0.003814610

368.09

-0.291576360

-10

0.003800114

424.63

-0.229519705

-9

0.003785728

456.96

-0.197652193

-8

0.003771450

530.73

-0.132656742

-7

0.003757280

598.37

-0.080560567

-6

0.003743215

676.23

-0.027435945

-5

0.003729256

755.54

0.020727083

Run 2

Temperature [°C]

Reciprocal temperature [K-1]

Mass difference [µg]

Log VP

-15

0.003873717

214.46

-0.526184077

-14

0.003858769

244.26

-0.469678026

-13

0.003843936

279.97

-0.410418881

-12

0.003829217

320.83

-0.351255407

-11

0.003814610

362.71

-0.297970849

-10

0.003800114

411.93

-0.242706957

-9

0.003785728

453.99

-0.200484092

-8

0.003771450

520.57

-0.141051242

-7

0.003757280

588.18

-0.088020126

-6

0.003743215

670.57

-0.031086259

-5

0.003729256

743.26

0.013610382

Run 3

Temperature [°C]

Reciprocal temperature [K-1]

Mass difference [µg]

Log VP

-15

0.003873717

215.27

-0.524546868

-14

0.003858769

248.30

-0.462553659

-13

0.003843936

281.15

-0.408592291

-12

0.003829217

315.05

-0.359150895

-11

0.003814610

363.61

-0.296894560

-10

0.003800114

406.76

-0.248192140

-9

0.003785728

473.74

-0.181990323

-8

0.003771450

528.59

-0.134411436

-7

0.003757280

595.53

-0.082626735

-6

0.003743215

663.16

-0.035912056

-5

0.003729256

750.23

0.017664048

Run 4

Temperature [°C]

Reciprocal temperature [K-1]

Mass difference [µg]

Log VP

-15

0.003873717

209.78

-0.535766298

-14

0.003858769

250.59

-0.458566643

-13

0.003843936

277.98

-0.413516828

-12

0.003829217

320.09

-0.352258272

-11

0.003814610

362.58

-0.298126534

-10

0.003800114

420.29

-0.233981322

-9

0.003785728

463.15

-0.191808710

-8

0.003771450

539.21

-0.125772441

-7

0.003757280

590.90

-0.086016389

-6

0.003743215

667.09

-0.033355948

-5

0.003729256

762.70

0.024823368

Run 5

Temperature [°C]

Reciprocal temperature [K-1]

Mass difference [µg]

Log VP

-15

0.003873717

205.46

-0.544803095

-14

0.003858769

240.78

-0.475909969

-13

0.003843936

282.80

-0.406050974

-12

0.003829217

320.15

-0.352176873

-11

0.003814610

358.09

-0.303538186

-10

0.003800114

412.07

-0.242559381

-9

0.003785728

460.82

-0.193999059

-8

0.003771450

520.27

-0.141301595

-7

0.003757280

592.99

-0.084483009

-6

0.003743215

658.04

-0.039278085

-5

0.003729256

749.41

0.017189105

Run 6

Temperature [°C]

Reciprocal temperature [K-1]

Mass difference [µg]

Log VP

-15

0.003873717

197.93

-0.561018754

-14

0.003858769

242.07

-0.473589409

-13

0.003843936

271.63

-0.423552645

-12

0.003829217

309.15

-0.367361128

-11

0.003814610

354.47

-0.307950893

-10

0.003800114

401.16

-0.254212756

-9

0.003785728

455.37

-0.199165963

-8

0.003771450

515.64

-0.145183779

-7

0.003757280

582.23

-0.092435800

-6

0.003743215

658.40

-0.039040557

-5

0.003729256

755.02

0.020428077

Run 7

Temperature [°C]

Reciprocal temperature [K-1]

Mass difference [µg]

Log VP

-15

0.003873717

210.50

-0.534278279

-14

0.003858769

240.50

-0.476415298

-13

0.003843936

274.82

-0.418482043

-12

0.003829217

310.42

-0.365580684

-11

0.003814610

355.17

-0.307094103

-10

0.003800114

399.36

-0.256165815

-9

0.003785728

450.08

-0.204240664

-8

0.003771450

516.03

-0.144855428

-7

0.003757280

578.28

-0.095392206

-6

0.003743215

653.41

-0.042344602

-5

0.003729256

752.02

0.018699012

Summary results:

Run

Slope

SE in slope

Intercept

SE in intercept

Log [VP(25 °C)]

1

-3.79E+03

46.8

14.2

0.178

1.45

2

-3.74E+03

27.7

14.0

0.105

1.42

3

-3.75E+03

29.7

14.0

0.113

1.43

4

-3.81E+03

48.0

14.2

0.182

1.45

5

-3.81E+03

49.9

14.2

0.190

1.45

6

-3.90E+03

50.4

14.6

0.192

1.48

7

-3.79E+03

19.2

14.1

0.0728

1.43

Mean

1.45

Vapour pressure

27.9 Pa

SE = standard error

The test item did not change in appearance under the conditions used in the determinations.

Conclusions:
A vapour pressure value of 28 Pa at 25°C was determined for the substance using a relevant test method and in compliance with GLP. The result is considered to be reliable.

Description of key information

Vapour pressure (Cyrene™): 28 Pa at 25°C (OECD 104)

Vapour pressure (Gem Diol): 0.4 Pa at 25°C (QSAR)

Key value for chemical safety assessment

Vapour pressure:
28 Pa
at the temperature of:
25 °C

Additional information

A vapour pressure value of 28 Pa at 25°C was determined for the submission substance using an effusion method - vapour pressure balance in accordance with OECD Test Guideline 104 and in compliance with GLP. The result is considered to be reliable.

 

This measured vapour pressure reflects the vapour pressure for Cyrene™ as placed on the market. In aqueous solution, Cyrene™ hydrates to form the Gem Diol; a separate vapour pressure is reported for this species.

A vapour pressure of 0.4 Pa at 25°C has been predicted for the Gem Diol form of Cyrene™ using an established QSAR method. The result is considered to be reliable. It is not possible to carry out an experimental vapour pressure study for the Gem Diol form because it is only present in aqueous solution.