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EC number: 807-130-4 | CAS number: 53716-82-8
The following correction was made to the NOAEL (oral): Correction respiratory volume rat (8 hour) 1/0.38 m³/kg bw/day, Correction for respiratory volume (worker): 6.7 m³/10 m³. Correction for oral to inhaled 1/2. Therefore the corrected NOAEC for repeated-dose systemic effects via the inhalation route is: 300*(1/0.38) *(6.7 m³/10 m³)*(1/2) = 264.5 mg/m³.
No correction was required to dose descriptor starting point.
The following correction was made to the NOAEL (oral): Correction respiratory volume rat (24 hour) 1/1.15 m³/kg bw. Correction for oral to inhaled 1/2. Therefore the corrected NOAEC for repeated-dose systemic effects via the inhalation route is: 300*(1/1.15)*(1/2) = 130.4 mg/m³.
In the presence of water, CyreneTM, with its anhydrous keto group [C=O], gains water (H2O) to form the corresponding hydrated Gem Diol [C(OH)2]. An equilibrium is established rapidly and is completely reversible. When the amount of water is reduced, the Gem Diol loses water, regenerating the anhydrous CyreneTM in its keto form. The ratio of the two forms depends upon the amount of water present and hence the polarity of the solution. Further information is available in the Physical and chemical properties endpoint summary (IUCLID Section 4).
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