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Environmental fate & pathways

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When CyreneTM is in aqueous solution, the keto group (C=O) gains water (H2O) to form the corresponding Gem Diol {(1S,5R)-6,8-dioxabicyclo[3.2.1]octane-4,4-diol}. An equilibrium is established rapidly (meaning that the reaction is rapidly reversible). The ratio of the two forms is dependent upon the amount of water present (see attached document in Section 13 for further details). At concentrations relevant for the environment (aquatic media) and in vivo, the Gem Diol form predominates. A log Kow value of -1.52 at 22.0 ± 1.0°C and pH 5.18 to 5.24 was determined for Cyrene™/Gem Diol. Therefore, the submission substance has low potential for bioaccumulation.