Registration Dossier

Diss Factsheets

Physical & Chemical properties

Partition coefficient

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From 04 to 09 June 2014
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
1.4
Temp.:
25 °C
Remarks on result:
other: pH unknown
Details on results:
The test substance was determined to have a log10Pow value of 1.4 (equivalent to a Pow value of 28).
Conclusions:
The test substance was found to have a log10Pow value of 1.4.
Executive summary:

Partition coefficient study for the test substance was conducted according to OECD Guideline 117 (HPLC method) under GLP. The test substance was found to have a Log10Pow value of 1.4.

Description of key information

The log Pow of the test substance is determined as 1.4 at 25℃.

Key value for chemical safety assessment

Log Kow (Log Pow):
1.4
at the temperature of:
25 °C

Additional information

Partition coefficient study for the test substance was conducted according to OECD Guideline 117 (HPLC method) under GLP. The test substance was found to have a Log10Pow value of 1.4.

In the study (Valvani, 1979), the log Pow of the test substance is determined as 1.48 at 25℃. This result was supported by EPA's tool "KOWWIN Program (v1.67)" where the Log Kow of the test substance was calculated as 1.71. In a further study (Inel, 1996), the log Pow of the test substance is calculated (using modelling) as 2.20, but the report could not be made available.