Registration Dossier
Registration Dossier
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EC number: 202-860-4 | CAS number: 100-52-7
Health surveillance data
Administrative data
- Endpoint:
- health surveillance data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Limited reported human patch test with large number of fragrances and their ingredients tested on 26 workers, no individual data
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
- Study type:
- health record from industry
- Endpoint addressed:
- skin sensitisation
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 5% the test substance in petrolatum patch tested according to the standard series following the ICDRG guidelines. The application time on the back was 2 days. The readings were taken on the Day 3 and Day 4.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Benzaldehyde
- EC Number:
- 202-860-4
- EC Name:
- Benzaldehyde
- Cas Number:
- 100-52-7
- Molecular formula:
- C7H6O
- IUPAC Name:
- benzaldehyde
- Details on test material:
- No data given
Constituent 1
Method
- Type of population:
- occupational
- Ethical approval:
- confirmed and informed consent free of coercion received
- Details on study design:
- To find out the causes of increasing number of skin diseases, first of all we carried out a site inspection at the factory (working condition, working process, work places), then a dermatological health survey of all 26 workers was accomplished. 5% the test substance in petrolatum patch tested according to the standard series following the ICDRG guidelines. The application time on the back was 2 days. The readings were taken on the D3 and D4. The concentrations were chosen because of the advice by Fisher.
Results and discussion
- Results:
- 9 positive reactions from the test substance were recorded in 18 out of 26 persons with 3 fragrance allergy reactions in the 6 eczema patients.
Applicant's summary and conclusion
- Conclusions:
- The test substance was one of the main causes of allergic contact dermatitis and positive patch test reactions.
- Executive summary:
5% the test substance in petrolatum patch tested according to the standard series following the ICDRG guidelines. The application time on the back was 2 days. The readings were taken on the Day 3 and Day 4.
The test substance was one of the main causes of allergic contact dermatitis and positive patch test reactions.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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