Registration Dossier
Registration Dossier
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EC number: 202-860-4 | CAS number: 100-52-7
Health surveillance data
Administrative data
- Endpoint:
- health surveillance data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Limited reported human patch test with large number of fragrances and their ingredients tested on 26 workers, no individual data
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
- Study type:
- health record from industry
- Endpoint addressed:
- skin sensitisation
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 5% the test substance in petrolatum patch tested according to the standard series following the ICDRG guidelines. The application time on the back was 2 days. The readings were taken on the Day 3 and Day 4.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Benzaldehyde
- EC Number:
- 202-860-4
- EC Name:
- Benzaldehyde
- Cas Number:
- 100-52-7
- Molecular formula:
- C7H6O
- IUPAC Name:
- benzaldehyde
- Details on test material:
- No data given
Constituent 1
Method
- Type of population:
- occupational
- Ethical approval:
- confirmed and informed consent free of coercion received
- Details on study design:
- To find out the causes of increasing number of skin diseases, first of all we carried out a site inspection at the factory (working condition, working process, work places), then a dermatological health survey of all 26 workers was accomplished. 5% the test substance in petrolatum patch tested according to the standard series following the ICDRG guidelines. The application time on the back was 2 days. The readings were taken on the D3 and D4. The concentrations were chosen because of the advice by Fisher.
Results and discussion
- Results:
- 9 positive reactions from the test substance were recorded in 18 out of 26 persons with 3 fragrance allergy reactions in the 6 eczema patients.
Applicant's summary and conclusion
- Conclusions:
- The test substance was one of the main causes of allergic contact dermatitis and positive patch test reactions.
- Executive summary:
5% the test substance in petrolatum patch tested according to the standard series following the ICDRG guidelines. The application time on the back was 2 days. The readings were taken on the Day 3 and Day 4.
The test substance was one of the main causes of allergic contact dermatitis and positive patch test reactions.
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