Registration Dossier

Administrative data

Endpoint:
short-term repeated dose toxicity: dermal
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
significant methodological deficiencies

Data source

Reference
Reference Type:
publication
Title:
About the pharmacologic and toxic activities of E-Caprolactam.
Author:
Hohensee F.
Year:
1951
Bibliographic source:
Faserforschung und Textiltechnik 8, 299-303

Materials and methods

Principles of method if other than guideline:
Four guinea-pigs each were dermally exposed (4x6 cm) to 5 and 10 % aqueous solution of Caprolactam daily for 62 days.

Test material

Constituent 1
Chemical structure
Reference substance name:
ε-caprolactam
EC Number:
203-313-2
EC Name:
ε-caprolactam
Cas Number:
105-60-2
Molecular formula:
C6H11NO
IUPAC Name:
azepan-2-one
Specific details on test material used for the study:
- Name of test material (as cited in study report): Caprolactam

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
water
Duration of treatment / exposure:
62 days
Frequency of treatment:
daily
Doses / concentrationsopen allclose all
Dose / conc.:
5 other: %
Remarks:
solution
Dose / conc.:
10 other: %
Remarks:
solution
No. of animals per sex per dose:
4

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

No alterations were observed.

No details concerning the applied volume of the test substance, therefore no quantitative assessment possible.

Applicant's summary and conclusion

Conclusions:
No alterations were observed.
No details concerning the applied volume of the test substance, therefore no quantitative assessment possible.
Executive summary:

Four guinea-pigs each were dermally exposed (4x6 cm) to 5 and 10 % aqueous solution of Caprolactam daily for 62 days.

No alterations were observed.

No details concerning the applied volume of the test substance, therefore no quantitative assessment possible.