Registration Dossier

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: secondary literature, no test substance characterization

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
The toxicity of caprolactam.
Author:
Lomonova, G.V. & Preobrazhenskaya, A.A.
Year:
1961
Bibliographic source:
Cited in: Questions of Working Hygiene and Clinic of Occupational Diseases, Gorky, 34-40.
Reference Type:
publication
Title:
The toxicity of caprolactam.
Author:
Lomonova, G.V. & Preobrazhenskaya, A.A.
Year:
1983
Bibliographic source:
Cited in: Izmerov, N.F. (ed.), IRPTC, Vol. 35: Caprolactam, Centre of International Projects, Moscow

Materials and methods

Principles of method if other than guideline:
no data
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Caprolactam

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Test system

Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
1-10 % and 25-50 % aqueous solution
Duration of treatment / exposure:
no data
Observation period (in vivo):
no data
Number of animals or in vitro replicates:
no data

Results and discussion

Any other information on results incl. tables

Conjunctival sac:
1-10 % aqueous solution: not irritant
25-50 % aqueous solution: irritant

Applicant's summary and conclusion