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EC number: 203-313-2
CAS number: 105-60-2
The test substance was rapidly absorbed from the stomach
and was distributed throughout all animals including fetuses. There was
efficient elimination by the kidney and liver, material secreted by the
liver into bile and intestinal contents appeared not to be reabsorbed
via an enterohepatic circulation. The kinetics of distribution and
elimination appeared to be the same in female and pregnant animals. The
only sites of retention of radioactivity after 24 hr (excluding renal
and hepatic) were in umbilical cords, amnion, yolk sac, maternal lens,
maternal Harder's gland, and maternal liver. The distribution into and
removal from the fetuses was typical of molecules that freely diffuse
across the placenta. There was no retention in any fetal tissue. No
localization was seen that would suggest a site of toxic action except
for that possibility in nasal epithelium.
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