Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-313-2
CAS number: 105-60-2
Minimal dermal irritation (grades 0 to ±) was observed in
both the test and negative control animals at challenge (table 1) and
rechallenge (data not shown). Group mean dermal scores were also
comparable between groups.
Table 1: Responding animals versus total animals in the
A modified Buehler test was performed. 20 female animals were indiced by
epidermal application of 0.4 ml (25% in water) of the test substance (3
times on 3 following weeks). 10 animals were included in the challenge
control group and 10 in rechallenge control group. The positive control
dinitrochlorobenzene (DNBC) was applied to 5 animals with additional 3
animals as DNBC challenge control.
Blood samples were collected before and after the test period. After
each induction, test sites were scored for dermal irritation. Following
a rest period of 14 days, animals were exposed to challenge dose.
A rechallenge was performed on the test and challenge control animals 7
days after the challenge procedure. The extent and degree of skin
reaction to the challenge exposure in the test animals is compared with
that demonstrated by control animals which undergo sham treatment during
induction and receive the challenge exposure.
Based on the results, the test substance is not considered a contact
sensitizer in guinea pigs under the conditions of this test.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again