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Toxicological information

Direct observations: clinical cases, poisoning incidents and other

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Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment
Remarks:
Article in Russian. Only abstract available in English.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Occupational diseases of the skin in the production of Caprolactam.
Author:
Antoniev, A.A. & Gerasimow, B.S.
Year:
1971
Bibliographic source:
Klin. Med. 49, 116
Reference Type:
publication
Title:
Occupational diseases of the skin in the production of Caprolactam.
Author:
Antoniev, A.A. & Gerasimow, B.S.
Year:
1971
Bibliographic source:
Cited in: Henschler, D., (Hrsg.), Gesundheitsschaedliche Arbeitsstoffe. Toxikologisch-arbeitsmedizinische Begruendung von MAK-Werten: Caprolactam (Nachtrag 1990), 1.-17. Lfg., Verlag Chemie (1991).

Materials and methods

Study type:
clinical case study
Endpoint addressed:
skin irritation / corrosion
Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
no data

Test material

Constituent 1
Chemical structure
Reference substance name:
ε-caprolactam
EC Number:
203-313-2
EC Name:
ε-caprolactam
Cas Number:
105-60-2
Molecular formula:
C6H11NO
IUPAC Name:
azepan-2-one
Specific details on test material used for the study:
- Name of test material (as cited in study report): Caprolactam

Method

Type of population:
occupational
Subjects:
- Number of subjects exposed: 453
Route of exposure:
dermal
Reason of exposure:
unintentional, occupational
Exposure assessment:
not specified

Results and discussion

Any other information on results incl. tables

During investigations of the pH of the skin surface and function of perspiration, there were early functional and biochemical alterations of the skin. Clinically the following occupational diseases of the skin were found: epidermitis (in 151 cases), dermatitis (in 21), eczema (in 8), urticaria (in 3), and skin itching (in 4). During investigation of the skin sensitivity to the test substance and other industrial allergens with the aid of drip skin tests 25.3% of persons had an increased sensitivity to the chemical. Limited imformation about the test substance.

Applicant's summary and conclusion

Conclusions:
Clinically the following occupational diseases of the skin were found: epidermitis (in 151 cases), dermatitis (in 21), eczema (in 8), urticaria (in 3), and skin itching (in 4).
Executive summary:

453 workers having occupational contact with the test substance and products of its synthesis were examined. During investigations of the pH of the skin surface and function of perspiration, there were early functional and biochemical alterations of the skin. Clinically the following occupational diseases of the skin were found: epidermitis (in 151 cases), dermatitis (in 21), eczema (in 8), urticaria (in 3), and skin itching (in 4). During investigation of the skin sensitivity to the test substance and other industrial allergens with the aid of drip skin tests 25.3% of persons had an increased sensitivity to the chemical.

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