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EC number: 201-178-4 | CAS number: 79-11-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 6-22 March 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: FDA guideline: federal register 38, no. 187, 27-09-1973, p 27019
- Deviations:
- not specified
- GLP compliance:
- no
- Remarks:
- did not exist at that time
Test material
- Reference substance name:
- Chloroacetic acid
- EC Number:
- 201-178-4
- EC Name:
- Chloroacetic acid
- Cas Number:
- 79-11-8
- Molecular formula:
- C2H3ClO2
- IUPAC Name:
- chloroacetic acid
- Details on test material:
- Monochloroessigsaure VA 2308. No further details specified.
Constituent 1
- Specific details on test material used for the study:
- crystalline flakes dissolved in physiological saline
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Himalayan
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Hoechst Aktiengesellschaft (breeding at the same laboratory)
- Weight at study initiation: 1.5-2.5 kg
- Housing: single housed
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
ENVIRONMENTAL CONDITIONS
no data
IN-LIFE DATES: From: 06-March 1979 To: 22-March 1979
Test system
- Vehicle:
- physiological saline
- Controls:
- not required
- Amount / concentration applied:
- 100 mg pasted with 0.01 mL vehicle
- Duration of treatment / exposure:
- Single application in one eye; the other one functioned as control
- Observation period (in vivo):
- 1, 7, 24, 48, and 72 h (however, due to welfare reasons animals were sacrificed at 24h)
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): rinsed with physiological saline.
- Time after start of exposure: 24h after treatment
SCORING SYSTEM: Appraisal of the safety of chemicals in foods, drugs and cosmetics, FDA, Austin , Texas, p. 51, 1975
The 48-h and 72-h observation was done after installation of a drop of Na-fluoroescien (0.01%).
Results and discussion
In vivo
Results
- Irritation parameter:
- other: Irritation index
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 106
- Max. score:
- 110
- Reversibility:
- not reversible
- Remarks on result:
- other: severe eye irration; animals were sacrificed after 24 h, no individual scores were given
- Remarks:
- In this older study other scoring criteria have been used
- Irritant / corrosive response data:
- Highest irritation index of 106 was observed at 7 and 24 h- mucous membrane was grey discoloured and corrosive.
Because of animal welfare reasons the study was terminated at 24 h. - Other effects:
- Not reported
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- Severely damaging to the eyes. Animals were sacrificed at 24 h due to welfare reasons.
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