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Toxicological information

Direct observations: clinical cases, poisoning incidents and other

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Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
other: case study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No detailed exposure assessment. Limited information available

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Pediatric fatality associated with accidental oral administration of monochloroacetic acid (MCA)
Author:
Feldhaus K, Hudson D, Brent J et al.
Year:
1993
Bibliographic source:
Vet. Hum. Toxicol. 35, 344
Reference Type:
publication
Title:
Accidental fatal monochloroacetic acid poisoning
Author:
Rogers DR
Year:
1995
Bibliographic source:
Am. J. Forensic Med. Pathol. 16(2): 115-116

Materials and methods

Study type:
poisoning incident
Endpoint addressed:
acute toxicity: oral
Test guideline
Qualifier:
no guideline followed
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Chloroacetic acid
EC Number:
201-178-4
EC Name:
Chloroacetic acid
Cas Number:
79-11-8
Molecular formula:
C2H3ClO2
IUPAC Name:
2-chloroacetic acid
Constituent 2
Reference substance name:
80% MCA wart remover (Verzone)
IUPAC Name:
80% MCA wart remover (Verzone)
Details on test material:
Not specified.

Method

Type of population:
general
Subjects:
one 5 year old girl
Ethical approval:
not applicable
Route of exposure:
oral
Reason of exposure:
accidental
Exposure assessment:
estimated
Details on exposure:
Accidental pediatric exposure to 5-6 cc (from a bottle resembling Triaminocol decongestant). A post-mortem serum MCA level of 100 microgram/L (determined by GC/MS) confirmed the ingestion.
Examinations:
Blood pressure, heart rate, respiratory rate, temperature, physical examination, blood analysis, autopsy
Medical treatment:
Resuscitation for 6 hours.

Results and discussion

Clinical signs:
Immediately after exposure: vomiting and collapse soon thereafter.
45 minutes after exposure: no distress, pale, slightly mottled skin.
Results of examinations:
1.5 hours post ingestion: refractory ventricular tachycardia, pulmonary oedema, and unmanagable metabolic acidosis.
8 hours after ingestion: death.
Autopsy: diffuse gastric erosions, marked gastric mucosal hyperaemia, fatty liver, and pulmonary and cerebral oedema.
Effectivity of medical treatment:
Not effective; patient died 8 hours post ingestion.
Outcome of incidence:
Death

Applicant's summary and conclusion

Conclusions:
Death occurred within 8 hours after ingestion of 5-6 cc 80% MCA in a 5-year old girl.