Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
201-178-4
CAS no.:
79-11-8
Index number:
Molecular formula:
C2H3ClO2
SMILES:
OC(=O)CCl
InChI:
InChI=1S/C2H3ClO2/c3-1-2(4)5/h1H2,(H,4,5)
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
20
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the harmonised classification and labelling (ATP01) approved by the European Union, this substance is toxic if swallowed, is toxic in contact with skin, causes severe skin burns and eye damage, is toxic if inhaled and is very toxic to aquatic life.

Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance is very toxic to aquatic life with long lasting effects, causes serious eye damage, may cause respiratory irritation and may be corrosive to metals.

Additionally, the classification provided by companies to ECHA in CLP notifications identifies that this substance is fatal in contact with skin and is fatal if inhaled.

Breakdown of all 1390 C&L notifications submitted to ECHA

Acute Tox. 3 H301 Harmonised Classification
Skin Corr. 1B H314 Harmonised Classification
Aquatic Acute 1 H400 Harmonised Classification
Acute Tox. 3 H311 Harmonised Classification
Acute Tox. 3 H331 Harmonised Classification
Eye Dam. 1 H318
STOT SE 3 H335
Acute Tox. 1 H330
Aquatic Chronic 1 H410
Acute Tox. 2 H310
Met. Corr. 1 H290
Acute Tox. 2 H330
STOT SE 3 H336
Aquatic Chronic 2 H411
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

At least one notifier has indicated that an impurity or an additive present in the substance impacts the notified classification.

Properties of concern

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 32 active registrations under REACH, 2 Joint Submission(s) and 3 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Seveso Annex I:
Industrial accident prevention and reporting requirements have been established for this substance.
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 10 000 to < 100 000 tonnes per annum.

This substance is used by consumers, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: cosmetics and personal care products.

Other release to the environment of this substance is likely to occur from: indoor use as processing aid.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

This substance is used in the following products: plant protection products, paper chemicals and dyes, pharmaceuticals, polymers and cosmetics and personal care products.

This substance is used in the following areas: agriculture, forestry and fishing, health services and scientific research and development. This substance is used for the manufacture of: chemicals and pulp, paper and paper products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, laboratory work, transfer of substance into small containers, mixing in open batch processes, production of mixtures or articles by tabletting, compression, extrusion or pelletisation and manual maintenance (cleaning and repair) of machinery.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use as processing aid.

This substance is used in the following products: plant protection products, polymers, biocides (e.g. disinfectants, pest control products), fertilisers, paper chemicals and dyes, pharmaceuticals and cosmetics and personal care products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, laboratory work, closed processes with no likelihood of exposure, closed batch processing in synthesis or formulation, closed, continuous processes with occasional controlled exposure and transfer of substance into small containers.

Release to the environment of this substance can occur from industrial use: formulation of mixtures and manufacturing of the substance.

This substance is used in the following products: polymers, plant protection products and biocides (e.g. disinfectants, pest control products). This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used for the manufacture of: chemicals and food products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed batch processing in synthesis or formulation, closed, continuous processes with occasional controlled exposure, laboratory work and batch processing in synthesis or formulation with opportunity for exposure.

Release to the environment of this substance can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates), manufacturing of the substance and for thermoplastic manufacture.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, laboratory work, closed, continuous processes with occasional controlled exposure and closed batch processing in synthesis or formulation.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

General statements

If medical advice is needed, have product container or label at hand.

Prevention statements

When handling this substance: keep only in original packaging; do not breathe the dust, fume, gas, mist, vapours or spray; avoid release to the environment; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier; avoid breathing the dust, fume, gas, mist, vapours or spray.

Response statements

In case of incident: If exposed or you feel unwell: call a poison center or doctor/physician. If swallowed: immediately call a poison center or doctor/physician. If on skin (or hair): take off immediately all contaminated clothing. Rinse skin with water or shower. Immediately call a poison center or doctor/physician. If in eyes: rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing. Collect spillage. Absorb spillage to prevent material damage. If swallowed: rinse mouth. Do not induce vomiting. If on skin: wash with soap and water.

Storage statements

Store this substance in a corrosive resistant container with a resistant inner liner (or in other specified container type); in a well-ventilated place and keeping container tightly closed.

Disposal statements

The substance must be disposed in accordance with local/regional/national/international regulation.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • Abbott Diagnostics GmbH, Max Planck Ring 2 D-65205 Delkenheim Hessen Germany
  • ADAMA Manufacturing Poland S.A., Sienkiewicza 4 56-120 Brzeg Dolny Poland
  • Ashland Services BV (0311), Noordweg 9 3336 LH Zwijndrecht Netherlands
  • CABB GmbH, Ludwig-Hermann-Str. 100 86368 Gersthofen Germany
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • Chemservice S.A. (U3PA), 13, Fausermillen 6689 Mertert Luxembourg
  • DuPont Nutrition Norge AS, Industriveien 33 N-1337 Sandvika Norway
  • Global Product Compliance (Europe) AB, IDEON, Beta 5, Scheelevägen 17 22363 Lund Sweden
  • Global Product Compliance (Europe) AB, IDEON, Beta 5, Scheelevägen 17 223 63 Lund Sweden
  • JACOBI CARBONS AB, Slojdaregatan 1 393 53 Kalmar Sweden
  • Jubilant Lifesciences NV, Axxes Business Park - Guldensporenpark 22 - block C 9820 Merelbeke Belgium
  • knoell Germany – OR – A15, Konrad-Zuse-Ring 25 68163 Mannheim Germany
  • Lamberti S.p.A., via Piave 18 21041 Albizzate Varese Italy
  • Meghmani Europe BVBA, Grote Steenweg 42/44 2600 Berchem Belgium
  • Nisso Chemical Europe GmbH, Berliner Allee 42 40212 Duesseldorf Germany
  • Nouryon Chemicals SPA, Via Vincenzo Gioberti 1 20123 Milano Milano Italy
  • Nouryon Industrial Chemicals B.V., Velperweg 76 6824 BM Arnhem Netherlands
  • Nufarm GmbH & Co.KG OR, St.-Peter-Str.25 4021 Linz Austria
  • PCC MCAA Sp. z o.o., Sienkiewicza 4 56-120 Brzeg Dolny Not Applicable Poland
  • Purolite Ltd., Llantrisant Business Park CF72 8LF Llantrisant Wales United Kingdom
  • REACH24H CONSULTING GROUP, Suite 1E, Paramount Court, Corrig Road, Sandyford Dublin 18 Dublin Ireland
  • REACH24H CONSULTING GROUP, Paramount Court, Corrig Road, Sandyford Dublin18 Dublin Ireland
  • REACHLINKED OÜ, Ahtri tn 12 10151 Tallinn Estonia
  • SCAS Europe S.A./N.V., Leonardo Da Vincilaan 19 B-1831 Diegem Belgium
  • Vink+Co GmbH Handelsgesellschaft und Co.KG, Eichenhöhe 24 21255 Kakenstorf Germany
  • Yordas GmbH, Äußere Nürnberger Str. 6 91301 Forchheim Germany
  • CABB Holding GmbH, Otto-Volger-Straße 3c 65843 Sulzbach Germany
  • Chemsafe S.r.l., Via Ribes 5 10010 Colleretto Giacosa (TO) Italy

Substance names and other identifiers

Acetic acid, 2-chloro-
Other
Acetic acid, chloro-
Other
Acide chloracetique
Other
Acide chloroacetique
Other
Acide monochloracetique
Other
Acidomonocloroacetico
Other
Chloracetic acid
Other
Chloroacetic acid
EC Inventory, C&L Inventory, REACH pre-registration, Other, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Pressure Equipment Directive - Group 1 Fluids Hazardous Substances, General Product Safety Directive - Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Physical, Biological and Chemical Agents & Processes and Work
CHLOROACETIC ACID SOLUTION
Inland Transport of Dangerous Goods Directive, Annex III - ADN, Inland Transport of Dangerous Goods Directive, Annex I - ADR, Inland Transport of Dangerous Goods Directive, Annex II - RID
CHLOROACETIC ACID, MOLTEN
Inland Transport of Dangerous Goods Directive, Annex III - ADN, Inland Transport of Dangerous Goods Directive, Annex I - ADR, Inland Transport of Dangerous Goods Directive, Annex II - RID
CHLOROACETIC ACID, SOLID
Inland Transport of Dangerous Goods Directive, Annex III - ADN, Inland Transport of Dangerous Goods Directive, Annex I - ADR, Inland Transport of Dangerous Goods Directive, Annex II - RID
Chloroethanoic acid
Other
Kyselina chloroctova
Other
MCA
Other
Monochloorazijnzuur
Other
Monochloracetic acid
Other
Monochloressigsaeure
Other
Monochloroacetic acid
Other
Monochloroethanoic acid
Other
acid cloroacetic (mt)
C&L Inventory
acide chloroacétique (fr)
C&L Inventory
acido cloroacetico (it)
C&L Inventory
chloorazijnzuur (nl)
C&L Inventory
chloracto rūgštis (lt)
C&L Inventory
chloreddikesyre (da)
C&L Inventory
Chloressigsäure (de)
C&L Inventory
chloroctová kyselina (cs)
C&L Inventory
hloretiķskābe (lv)
C&L Inventory
Kloorietikkahappo (fi)
C&L Inventory
kloreddiksyre (no)
C&L Inventory
kloroctena kiselina (hr)
C&L Inventory
kloroocetna kislina (sl)
C&L Inventory
kloroäädikhape (et)
C&L Inventory
klorättiksyra (sv)
C&L Inventory
klórecetsav (hu)
C&L Inventory
kwas chlorooctowy (pl)
C&L Inventory
kyselina chlóroctová (sk)
C&L Inventory
ácido cloroacético (es)
C&L Inventory
χλωροξικό οξύ (el)
C&L Inventory
хлорооцетна киселина (bg)
C&L Inventory
2-Chloro-ethanoic acid
C&L Inventory, Registration dossier
2-chloroacetic acid
C&L Inventory, Registration dossier, Other
acetyl chloride
C&L Inventory, Registration dossier
Choloacetic acid
C&L Inventory
Monochloro Acetic Acid
Registration dossier
MONOCHLOROACETIC ACID (MCAA)
Registration dossier
Monochloroacetic acid (Solid) [MCA]
Registration dossier
Polyanionic Cellulose Polymer
Registration dossier
Sodium Carboxymethyl Cellulose
Registration dossier
607-003-00-1
Index number
C&L Inventory
79-11-8
CAS number
EC Inventory, C&L Inventory, Registration dossier, REACH pre-registration, Other, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, Inland Transport of Dangerous Goods Directive, Annex III - ADN, Inland Transport of Dangerous Goods Directive, Annex I - ADR, Inland Transport of Dangerous Goods Directive, Annex II - RID, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Pressure Equipment Directive - Group 1 Fluids Hazardous Substances, General Product Safety Directive - Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Physical, Biological and Chemical Agents & Processes and Work

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 9 studies submitted
  • 3 studies processed
C Physical state at 20°C and 1013 hPa
Solid (100%) [3]
C Form
Crystalline (33%), Flakes (33%), Other (33%) [3]
C Odour
Faint (100%) [1]
C Substance type
Organic (100%) [2]

Type of Study provided
Studies with data
Key study 1 1
Supporting study 3 1
Weight of evidence 1 1
Other 1
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Physical state at 20°C and 1013 hPa
Solid (100%)

Melting/freezing point

Study results
  • 10 studies submitted
  • 3 studies processed
R Melting / freezing point
61.3 - 63 °C @ 101.3 - 101.325 kPa [3]

Type of Study provided
Studies with data
Key study 2 1
Supporting study 5 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Melting / freezing point at 101 325 Pa
63 °C

Boiling point

Study results
  • 10 studies submitted
  • 3 studies processed
R Boiling point
189.3 - 190 °C @ 101.3 - 101.325 kPa [3]

Type of Study provided
Studies with data
Key study 2 1
Supporting study 5 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Boiling point at 101 325 Pa
190 °C

Density

Study results
  • 9 studies submitted
  • 3 studies processed
R Density
1.4 - 1.64 g/cm³ @ 20 °C [2]
R Relative density
1.404 - 1.64 @ 20 - 55 °C [3]

Type of Study provided
Studies with data
Key study 2 1
Supporting study 4 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Relative density at 20°C
1.64

Vapour pressure

Study results
  • 6 studies submitted
  • 3 studies processed
R Vapour pressure
2.14 - 3 220 Pa @ 20 - 80 °C [4]

Type of Study provided
Studies with data
Key study 2 1
Supporting study 1 1 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Vapour pressure
2.14 Pa @ 20 °C

Partition coefficient

Study results
  • 6 studies submitted
  • 3 studies processed
R Pow
3.09 [1]
R Log Pow
0.22 - 0.49 [3]

Type of Study provided
Studies with data
Key study 2 1
Supporting study 2 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Log Kow (Log Pow)
0.49 @ 20 °C

Water solubility

Study results
  • 6 studies submitted
  • 3 studies processed
R Water solubility (mass/vol.)
8.58 - 4 210 000 mg/L @ 20 - 25 °C and pH 0.86 [3]

Type of Study provided
Studies with data
Key study 2 1
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Water solubility
1 000 g/L @ 20 °C

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 2 studies submitted
  • 1 study processed
R Surface tension
73.1 mN/m @ 1 g/L and 20 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 1 summary submitted
  • 1 summary processed
Surface tension at 20 °C
73.1 mN/m @ 1 mg/L

Flash point

Study results
  • 5 studies submitted
  • 1 study processed
R Flash point
126 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 2
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Auto flammability

Study results
  • 3 studies submitted
  • 1 study processed
R Autoflammability / self-ignition
475 °C @ 101.19 - 102.2 kPa [1]

Type of Study provided
Studies with data
Key study 1 1
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Autoflammability / self-ignition at 101 325 Pa
475 °C

Flammability

Study results
  • 4 studies submitted
  • 1 study processed
C Interpretation of results
Non flammable (100%) [1]

Type of Study provided
Studies with data
Key study 1 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Flammability
Non flammable (100%)

Explosiveness

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
C Summaries
  • 1 summary submitted
  • 1 summary processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Oxidising
No (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 1 study submitted
  • 1 study processed
C Dissociating properties
Yes (100%) [1]
R Dissociation constant
2.8 @ 20 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
pKa at 20 °C
2.8

Viscosity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Hydrolysis

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 14 studies submitted
  • 1 study processed
C Interpretation of results
Readily biodegradable (100%) [1]

Type of Study provided
Studies with data
Key study 1 1
Supporting study 6 4
Weight of evidence
Other 2
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Biodegradation in water
Readily biodegradable (100%)
Type of water
Freshwater (100%)

Biodegradation in water & sediment - simulation tests

Data not provided by the registrant

Biodegradation in soil

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 1
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: aquatic / sediment

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 1 summary submitted
  • 1 summary processed
Koc at 20°C
0.73

Henrys law constant (H)

Data not provided by the registrant

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 1 summary submitted
  • 1 summary processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 700 ng/L (1)
Intermittent releases (freshwater) 330 ng/L (1)
Marine water 70 ng/L (1)
Intermittent releases (marine water) 33 ng/L (1)
Sewage treatment plant (STP) 1.6 mg/L (1)
Sediment (freshwater) 2.57 µg/kg sediment dw (1)
Sediment (marine water) 257 ng/kg sediment dw (1)
Hazard for Air
Air No hazard identified (1)
Hazard for Terrestrial Organism
Soil 6 µg/kg soil dw (1)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (1)

Short–term toxicity to fish

Study results
  • 11 studies submitted
  • 2 studies processed
P/RResults
LC50 (4 days) 71.7 - 369 mg/L [3]
LC0 (4 days) 43.5 - 44.1 mg/L [2]
LC100 (4 days) 98.9 - 99.1 mg/L [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other 1 6
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
NOEC (35 days) 12.5 - 25 mg/L [2]
LOEC (35 days) 25 mg/L [1]
LC50 (35 days) 57 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 8 studies submitted
  • 1 study processed
P/RResults
EC50 (48 h) 74.2 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1 2
Weight of evidence
Other 3
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 2 studies submitted
  • 1 study processed
P/RResults
NOEC (21 days) 32 mg/L [1]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 7 studies submitted
  • 2 studies processed
P/RResults
EC50 (72 h) 25 - 158 µg/L [4]
NOEC (72 h) 5.8 - 33.1 µg/L [4]
EC10 (72 h) 6 - 7 µg/L [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other 1 2
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for freshwater algae
33 µg/L
EC10 or NOEC for freshwater algae
7 µg/L

Toxicity to aquatic plants other than algae

Study results
  • 2 studies submitted
  • 1 study processed
P/RResults
EC50 (14 days) 5.5 - 6.6 mg/L [2]
EC10 (14 days) 2.4 - 3 mg/L [2]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for freshwater plants
5.8 mg/L

Toxicity to microorganisms

Study results
  • 7 studies submitted
  • 1 study processed
P/RResults
IC50 (36 h) 16 mg/L [1]
IC50 (9 h) 83 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 3 1
Weight of evidence
Other 1 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for microorganisms
16 mg/L

Sediment toxicity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial arthropods

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial plants

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
NOEC (21 days) 3.2 - 32 mg/kg soil dw [9]
EC50 (21 days) 9.2 - 100 mg/kg soil dw [9]
EC25 (21 days) 2 - 81.3 mg/kg soil dw [9]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Long-term EC10 / LC10 / NOEC
600 µg/kg soil dw

Toxicity to soil microorganisms

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to birds

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 1 summary submitted
  • 1 summary processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 4 mg/m³ repeated dose toxicity
Acute /short term: Low hazard (no threshold derived)
Local Effects
Long-term: (DNEL) 2 mg/m³ repeated dose toxicity
Acute /short term: (DNEL) 5.7 mg/m³ irritation (respiratory tract)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: Medium hazard (no threshold derived)
Acute /short term: (Medium hazard (no threshold derived)) -
Local Effects
Long-term: Medium hazard (no threshold derived)
Acute /short term: Medium hazard (no threshold derived)
EYE Exposure
Medium hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 1 mg/m³ repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: (DNEL) 500 µg/m³ repeated dose toxicity
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 35 µg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
EYE Exposure
No hazard identified

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 16 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study
Supporting study 13 1
Weight of evidence
Other 2
Data waiving
no waivers
Study data: dermal absorption
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation potential:
Low bioaccumulation potential
Absorption values
Oral: 100 %
Dermal: 90 %

Acute toxicity

Study results
oral
  • 8 studies submitted
  • 1 study processed
P/RResults
LD50 90.4 mg/kg bw (rat) [1]
M/CInterpretations of results
Category 3 based on GHS criteria [1]

Type of Study provided
oral
Studies with data
Key study 1
Supporting study 3 1
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
inhalation
  • 4 studies submitted
  • 1 study processed
P/RResults
LC50 (4 h) 1.268 mg/L air (rat) [1]
M/CInterpretations of results
GHS criteria not met [1]

inhalation
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 1 1
Data waiving
no waivers
dermal
  • 6 studies submitted
  • 1 study processed
P/RResults
LD50 305 mg/kg bw (rat) [1]
M/CInterpretations of results
Category 3 based on GHS criteria [1]

dermal
Studies with data
Key study 1
Supporting study 3
Weight of evidence
Other 2
Data waiving
no waivers
other routes
  • 10 studies submitted
  • 0 studies processed

No automatically processable data submitted

other routes
Studies with data
Key study
Supporting study 8
Weight of evidence
Other 2
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route:
Adverse effect observed LD50 90 mg/kg bw
Dermal route:
Adverse effect observed LD50 305 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Study data: eye
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin
Adverse effect observed (corrosive)
Eye
Adverse effect observed (irreversible damage)
Respiratory
Adverse effect observed (irritating)

Sensitisation

Study results
Study data: skin
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1 1
Supporting study
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No study available

Repeated dose toxicity

Study results
Study data: oral
  • 8 studies submitted
  • 1 study processed
P/RResults
LOAEL (rat): 30 mg/kg bw/day [1]

Type of Study provided
Study data: oral
Studies with data
Key study 1
Supporting study 4 1
Weight of evidence
Other 2
Data waiving
no waivers
Study data: inhalation
  • 0 studies submitted
  • 0 studies processed

No data available

Study data: inhalation
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal
  • 0 studies submitted
  • 0 studies processed

No data available

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route - systemic effects:
Adverse effect observed LOAEL 30 mg/kg bw/day (subchronic, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 34 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 4 1
Supporting study 27
Weight of evidence
Other 2
Data waiving
no waivers
Study data: in vivo
  • 9 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 2
Supporting study 4
Weight of evidence
Other 1 2
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Toxicity - InVitro
No adverse effect observed (negative)
Toxicity - InVivo
No adverse effect observed (negative)

Carcinogenicity

Study results
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 3
Supporting study 1
Weight of evidence
Other 2
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route:
Adverse effect observed NOAEL 3.5 mg/kg bw/day (chronic, rat)

Toxicity to reproduction

Study results
Study data: reproduction
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 1
Supporting study 1 1
Weight of evidence
Other 1
Data waiving
no waivers
Study data: developmental
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 1
Supporting study 1 1
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Neurotoxicity

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study 2
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant