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Toxicological information

Additional toxicological data

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Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature

Data source

Reference
Reference Type:
publication
Title:
COMPARISON OF CYTOTOXIC EFFECTS OF CHEMICALS IN FOUR DIFFERENT CELL TYPES
Author:
Sasaki, K. et al.
Year:
1991
Bibliographic source:
Toxic. in Vitro 5(5/6): 403-406

Materials and methods

Type of study / information:
Cytotoxicity
Principles of method if other than guideline:
Cytotoxic effects were compared using a colony-formation assay in three established cell lines (BaIb 3T3, mouse whole embryo, ARLJ301-3, rat liver and FRSK, rat keratinocytes) and one primary cell culture (RC-1, rabbit cornea) with the Draize eye irritancy score in vivo.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Specific details on test material used for the study:
- Name of test material (as cited in study report): 2-Phenoxyethanol
- Analytical purity: no data

Results and discussion

Any other information on results incl. tables

These results suggest that the colony-formation assay using established cell lines is an attractive method for the screening of chemicals in that large differences among cell types in their response to direct-acting chemicals, were not observed.

Applicant's summary and conclusion