Registration Dossier

Administrative data

Description of key information

2-Phenoxyethanol is not irritating to rabbit skin, but irritating to the eyes.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

Skin irritation:

A mild primary irritation was observed in one rabbit 1 hour after application, which was reversible within 24 hours (BASF AG, 1983). Although the test conditions were not in full accordance with OECD guideline 404, the results should be considered representative for the toxicological properties of 2-phenoxyethanol. 2-Phenoxyethanol was not an irritant to rabbit skin.

According to OECD 404, the skin irritation potential of 2-phenoxyethanol was determined (Sasol, 1983).The test substance was applied to the intact skin of rabbits for 4 hours under occlusive conditions. After removal of the test substance, no oedema, but very slight erythema were noted in 2 of 6 animals. All erythema were reversible within 48 hours. Under the test conditions, 2-Phenoxyethanol was not irritating to the skin.

Eye irritation: The single application of 0.1 mL unchanged test material in the eye of each of 3 rabbits clearly induced signs of irritation in all 3 animals; the signs were of maximal severity between 48 and 72 hours following application (BASF AG, 1983). Thereafter, a tendency to reversibility was observed and after 15 days, only one animal still displayed slight corneal opacity affecting less than ¼ of the corneal area of the treated eye. The test substance 2-phenoxyethanol is therefore considered an eye irritant.

Effects on eye irritation: irritating

Effect level: empty Endpoint conclusion: Adverse effect observed

Justification for classification or non-classification

Skin irritation: not irritating to skin.

Eye Irritation:

EU: Xi R36

CLP: Cat. 2