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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1963
Report date:
1963

Materials and methods

Principles of method if other than guideline:
BASF-Test on acute toxicity (determination of LD50) in mice after i.p. application.
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-phenoxyethanol
EC Number:
204-589-7
EC Name:
2-phenoxyethanol
Cas Number:
122-99-6
Molecular formula:
C8H10O2
IUPAC Name:
2-phenoxyethan-1-ol
Specific details on test material used for the study:
- Name of test material (as cited in study report): Arophor
- Analytical purity: no data

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
other: tracaganth
Doses:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
333 mg/kg bw

Any other information on results incl. tables

Clinical signs: Apathy, prone position, narcotic state, morphine tail, opisthotonos, secretion of the conjunctiva, anaesthesia-like state and delayed mortality were observed (no further details).

LD50 ca. 300 microliters/kg (original finding, corresponding to approx. 333 mg/kg bw)

Applicant's summary and conclusion