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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: basic data given

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Final report on safety assessment of phenoxyethanol.
Author:
Anonymous
Year:
1990
Bibliographic source:
J. Am. Coll. Toxicol. 9(2): 259 -277
Reference Type:
study report
Title:
Unnamed
Year:
1980

Materials and methods

Principles of method if other than guideline:
The acute dermal toxicity of undiluted phenoxyethanol was evaluated using 10 CFY rats.
GLP compliance:
no
Test type:
other: acute dermal toxicity test
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): 2-phenoxyethanol
- Physical state: liquid
- Analytical purity: purity was not confirmed but is listed by the manufacturer to be > 99%

Test animals

Species:
rat
Strain:
other: CFY
Sex:
male/female

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
TEST SITE
- Area of exposure: dorsolumbar region
- % coverage: 10% of the total body surface
Duration of exposure:
24 h
Doses:
1-22.2 mL/kg
No. of animals per sex per dose:
5
Control animals:
no
Details on study design:
- Duration of observation period following administration: 48 hours
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
14 391 mg/kg bw
Remarks on result:
other: which is equivalent to 13 mL/kg bw
Mortality:
Death occurred 21-48 h after dosing.
Gross pathology:
Hemorrhagic lungs were found at necropsy.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
CLP: not classified