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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1980
Report Date:
1980
Reference Type:
publication
Title:
Final report on the safety assessment of phenoxyethanol
Author:
Anonymous
Year:
1990
Bibliographic source:
J. Am. Coll. Toxicol. 9(2): 259-277
Reference Type:
secondary source
Title:
Ethylene Glycol Phenyl Ether
Author:
OECD SIDS
Year:
2004
Bibliographic source:
UNEP Publications
Reference Type:
study report
Title:
Unnamed
Year:
1982
Report Date:
1982

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: Draft IRLG (Interagency Regulatory Liaison Group) Guidelines for Selected Acute Toxicity Tests (August. 1979)
Deviations:
no
GLP compliance:
no
Remarks:
GLP was not compulsory at the time the study was performed
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Specific details on test material used for the study:
- Name of test material (as cited in study report): 2-phenoxyethanol, "Cosmetical grade"
- Physical state: liquid
- Analytical purity: Not given, however assumed to be ca. 92% 2-phenoxyethanol, ca. 8% Diethylenglykolmonophenylether (cosmetical grade)
- Lot/batch No.: sample number: 2219-93

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male/female
Details on test animals and environmental conditions:
TEST ANIMALS
- Source: Plummers Rabbit Ranch
- Weight at study initiation: 2500- 2780 g

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
REMOVAL OF TEST SUBSTANCE
- Washing (if done): with water
- Time after start of exposure: 24 h

TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 5-5.6 mL
Duration of exposure:
24 h
Doses:
2 mL/kg (corresponding to 2214 mg/kg bw; based on a density of 1.107 g/mL)
No. of animals per sex per dose:
4
Control animals:
no
Details on study design:
Test was performed on abraded skin only.
- Duration of observation period following administration: 14 days

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 214 mg/kg bw

Applicant's summary and conclusion