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EC number: 204-589-7 | CAS number: 122-99-6
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The NOEC (34 days) of 2-phenoxyethanol in an early-life stage toxicity test with Pimephales promelas was determined to be 24 mg/L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 24 mg/L
Additional information
A test on early life-stage toxicity of
2-phenoxyethanol to embryos, larvae and juvenile fish of the fathead
minnow (Pimephales promelas) was performed according to OECD
guideline 210 and EPA-FIFRA guidelines (BASF 2005). Fertilized eggs were
exposed to following (nominal) concentrations of 2-phenoxyethanol
(purity > 99.9%) under flow-through conditions for 34 days: 0, 10, 23,
50, 110 and 220 mg a.i./L. Test parameters were mortality of embryos,
number of surviving larvae, survival of young fish, time to hatch and
swim-up, toxic sign (symptoms) and abnormalities, and weight and total
length of surviving fish.
In conclusion, the NOEC for survival was 23 mg/L (nominal concentration)
and 24 mg/L (based on the mean analytically determined concentration),
and the LOEC was 50 mg/L (nominal concentration) and 51.3 mg/L
(analytical concentration). For sublethal effects, the NOEC was 110 mg/L
and 105.5 mg/L for nominal and analytical concentration, respectively,
while the LOEC was 220 mg/L and 215 mg/L for nominal and analytical
concentration, respectively. For the development of body weight, the
NOEC was 50 mg/L and 51.3 mg/L for nominal and analytical concentration,
respectively, and the LOEC was 110 mg/L (nominal) and 105.5 mg/L
(analytical). For development of body length of the surviving fish at
the end of the exposure period, the NOEC and LOEC values equal those
from development of body weight.
A supporting study according to OECD 212 with Danio rerio (fertilized eggs and embryonal stages) found an LC50 of 486 ± 26 mg/L when treated with five concentrations of 2-phenoxyethanol in a semi-static system (Macova et al. 2008).
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