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Toxicological information

Direct observations: clinical cases, poisoning incidents and other

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Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
other: Biomonitoring and exposure data
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: basic data given

Data source

Reference
Reference Type:
publication
Title:
Biologisches Monitoring zur Expositionserfassung von 2-Phenoxyethanol in der Allgemeinbevölkerung
Author:
Göen, T. et al.
Year:
2001
Bibliographic source:
Verhl. Dt. Ges. Arbeitsmed. Umweltmed., 41. Jahrestagung, Erlangen: 212–216

Materials and methods

Study type:
study with volunteers
Endpoint addressed:
neurotoxicity
Principles of method if other than guideline:
not applicable
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): 2-Phenoxyethanol
- Analytical purity: no data

Method

Type of population:
occupational
Subjects:
- Number of subjects exposed: 379 workers
Ethical approval:
not applicable
Route of exposure:
dermal
Reason of exposure:
other: use of skin care products at work and at home
Exposure assessment:
not specified
Examinations:
Detection of 2-phenoxyethanol in urine

Results and discussion

Clinical signs:
not examined
Results of examinations:
- Urine analysis: In 89 % of the samples 2-phenoxyethanol was detected (>= 0.1 mg/l, Cmax= 151 mg/l). In the rotation printing area significantly elevated 2-phenoxyethanol levels were detected compared to the delivery area.

Applicant's summary and conclusion