Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-589-7 | CAS number: 122-99-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
The EC50 (72h) for 2-phenoxyethanol regarding effects on algal biomass was > 100 mg/L, the corresponding NOEC (72h) was 46 mg/L.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 100 mg/L
- EC10 or NOEC for freshwater algae:
- 46 mg/L
Additional information
The key study examined the effects of 2-phenoxyethanol on growth rate on Desmodesmus subspicatus according to OECD 201 (BASF and DOW 2012). The test was repeated three times. The first one was not reported since the validity criteria failed. The toxicity was determined in a static system at nominal concentrations of 0, 10, 22, 46 and 100 mg/L (second test) and at nominal 100 mg/L (third test). The EC50 after 72 hours based on growth rate was > 100 mg/L and the NOEC was 46 mg/L. The measured concentrations were within 20% of the nominal concentrations and thus the endpoints were related to the nominal levels.
In the further study, an algal growth inhibition test was performed on the toxicity of 2-phenoxyethanol to the freshwater algae Scenedesmus subspicatus according to DIN 38412 Part 9 (BASF AG, 1989). The toxicity was determined in a static system at the nominal concentrations 0, 7.812, 15.625, 31.25, 62.5, 125, 250 and 500 mg a.i./L resulting in an EC50 for growth after 72 hours of > 500 mg/L and a NOEC of ≥ 500 mg/L.
Another study examined the effects of 2-phenoxyethanol on biomass, growth rate and growth inhibition on Scenedesmus subspicatus according to EU method C.3 (Sasol Germany GmbH, 1994). The toxicity was determined in a static system at nominal concentrations of 0, 70, 120, 200, 360, 600 and 1000 mg/L resulting in an EC50 for biomass after 72 hours of 443 mg/L and an EC10 (72h) of 159 mg/L. The EC50 after 72 hours based on growth rate was 625 mg/L and the EC10 (72 h) was 333 mg/L. The NOEC (72h) based on growth rate was 70 mg/L.
A publication that documented a guideline limit study using Psuedokirchneriella subcapitata reported that no effects were seen at the single tested concentration of 130mg/l. This result is consistent with those reported above.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
