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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
significant methodological deficiencies
Remarks:
Does not meet criteria of a guideline study; route of exposure not relevant

Data source

Reference
Reference Type:
publication
Title:
Biologically active|compounds of silicon.
Author:
Voronkov, M.G. and Lukevics, E.
Year:
1969
Bibliographic source:
Russian Chem Reviews 38: 975-986

Materials and methods

Test guideline
Qualifier:
no guideline followed
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Hexamethyldisiloxane
EC Number:
203-492-7
EC Name:
Hexamethyldisiloxane
Cas Number:
107-46-0
Molecular formula:
C6H18OSi2
IUPAC Name:
hexamethyldisiloxane

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
not specified
Doses:
No data
No. of animals per sex per dose:
No data
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
4 500 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No further details available

Applicant's summary and conclusion

Conclusions:
In an acute intraperitoneal study (reliability score 3) no deaths occurred after injection of 4500 mg/kg bw HMDS to mice (no further details available).

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