Registration Dossier

Diss Factsheets

Toxicological information

Immunotoxicity

Currently viewing:

Administrative data

Description of key information

There are no reliable data for this endpoint.

Key value for chemical safety assessment

Effect on immunotoxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no study available

Effect on immunotoxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Effect on immunotoxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

An early research study designed to investigate possible actions of structurally related polydimethylsiloxanes on the reticuloendothelial system was conducted on mice in vivo. In in vivo preliminary studies structurally related polydimethylsiloxanes showed no effect on the serum interferon titre at 2 hr post induction in mice (Dow Corning Corporation, 1975). The study reports for these studies are not available and therefore the reliability cannot be verified.

Justification for classification or non-classification

Based on the available limited data, HMDS does not meet the criteria for classification for immunotoxic effects according to Regulation (EC) 1272/2008.

Categories Display