Registration Dossier
Registration Dossier
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EC number: 203-492-7 | CAS number: 107-46-0
Immunotoxicity
Administrative data
Description of key information
There are no reliable data for this endpoint.
Key value for chemical safety assessment
Effect on immunotoxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Effect on immunotoxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Effect on immunotoxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
An early research study designed to investigate possible actions of structurally related polydimethylsiloxanes on the reticuloendothelial system was conducted on mice in vivo. In in vivo preliminary studies structurally related polydimethylsiloxanes showed no effect on the serum interferon titre at 2 hr post induction in mice (Dow Corning Corporation, 1975). The study reports for these studies are not available and therefore the reliability cannot be verified.
Justification for classification or non-classification
Based on the available limited data, HMDS does not meet the criteria for classification for immunotoxic effects according to Regulation (EC) 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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