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Toxicological information

Additional toxicological data

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Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
No data
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Original study report not available for review.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1984

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Dow Corning, Health Care Research S.O.P. Nos. 407 and 408
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Hexamethyldisiloxane
EC Number:
203-492-7
EC Name:
Hexamethyldisiloxane
Cas Number:
107-46-0
Molecular formula:
C6H18OSi2
IUPAC Name:
hexamethyldisiloxane

Results and discussion

Any other information on results incl. tables

A distinct cytopathic effect was observed by the test substance in initial and retesting of the samples.

Applicant's summary and conclusion

Conclusions:
In an in vitro assay (reliability score 4), hexamethyldisiloxane produced a distinct cytopathic effect in initial testing and retesting of the samples in human embryonic cells.

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