Registration Dossier

Diss Factsheets

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
other: clinical observations
Adequacy of study:
supporting study
Study period:
No data
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Insufficient details to determine reliability

Data source

Reference
Reference Type:
publication
Title:
No data
Author:
Vrba, J.
Year:
1956
Bibliographic source:
Pracovni Lekarstvi, Vol 8, 210

Materials and methods

Study type:
other: Direct observation
Test guideline
Qualifier:
no guideline available
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Hexamethyldisiloxane
EC Number:
203-492-7
EC Name:
Hexamethyldisiloxane
Cas Number:
107-46-0
Molecular formula:
C6H18OSi2
IUPAC Name:
hexamethyldisiloxane

Method

Subjects:
No data
Route of exposure:
inhalation
Reason of exposure:
intentional

Results and discussion

Clinical signs:
Inhalation of the vapor of hexamethyldisiloxane by humans was reported to produce a slight irritation of the lungs, skin and eyes.

Applicant's summary and conclusion

Conclusions:
In a clinical assessment (reliability score 4), inhalation of the vapor of hexamethyldisiloxane by humans was reported to produce a slight irritation of the lungs, skin and eyes.