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EC number: 203-492-7 | CAS number: 107-46-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- not in compliance with GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- Hilltop-Wistar albino rats, weighing between 200 and 300 g, received the test material by stomach intubation with a ball-end stainless steel needle. The sample was injected through the needle by means of a syringe and doses were varied by adjusting the volume of the test material. The rats were fasted overnight before dosing. Five males and 5 females were included on each level (16.0 and 8.0 ml/kg).
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Hexamethyldisiloxane
- EC Number:
- 203-492-7
- EC Name:
- Hexamethyldisiloxane
- Cas Number:
- 107-46-0
- Molecular formula:
- C6H18OSi2
- IUPAC Name:
- trimethyl[(trimethylsilyl)oxy]silane
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Hilltop-Wistar albino
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- weighing between 200 and 300 g
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- VEHICLE: Not applicable
MAXIMUM DOSE VOLUME APPLIED: Not stated - Doses:
- 8.0 and 16.0 ml/kg
- No. of animals per sex per dose:
- 5/sex/group
- Control animals:
- no
- Details on study design:
- Hilltop-Wistar albino rats, weighing between 200 and 300 g, received the test material by stomach intubation with a ball-end stainless steel needle. The sample was injected through the needle by means of a syringe and doses were varied by adjusting the volume of the test material. The rats were fasted overnight before dosing. Five males and 5 females were included on each level (16.0 and 8.0 ml/kg). The animals were maintained on appropriate commercial diet and municipal water. Both were available ad libitum except during period of fasting, manipulation or restraint. Animal weights were recorded at 0 days (before dose), 7 days and 14 days (just prior to sacrifice). At death or sacrifice, each animal was subjected to gross pathologic evaluation.
- Statistics:
- LD50s were calculated by the moving average method (Thompson, 1947) and were based on a 14-day observation period.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 16 mL/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: corresponding to 12.16 g/kg
- Mortality:
- MALES:
16.0 ml/kg Dead/Dosed: 0/5
8.0 ml/kg Dead/dosed: 1/5
FEMALES:
16.0 ml/kg Dead/Dosed: 0/5
8.0 ml/kg Dead/Dosed: 0/5 - Clinical signs:
- other: MALES: 16.0 ml/kg None noted. 8.0 ml/kg: In the animal that died, sluggishness, unsteady gait at 4 min; death at 15 min. In survivors, none noted. FEMALES: 16.0 ml/kg None noted. 8.0 ml/kg None noted.
- Gross pathology:
- MALES:
16.0 ml/kg : Nothing remarkable.
8.0 ml/kg In animal that died, lungs with dark spots; liver dark; stomach liquid-filled, injected; intestines and kidneys red. In survivors, nothing remarkable.
FEMALES:
16.0 ml/kg : Nothing remarkable.
8.0 ml/kg Nothing remarkable. - Other findings:
- No other findings reported.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute oral LD50 was determined to be > 16.0 ml/kg, dosed as received, in both male and female rats.
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