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Long-term toxicity to fish

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Description of key information

The chemical safety assessment according to Annex I of Regulation (EC) No. 1907/2006 does not indicate the need to further investigate the long-term toxicity to fish.

Key value for chemical safety assessment

Additional information

Experimental data on the long-term toxicity of Glycine are not available. However, the chemical safety assessment according to Annex I of Regulation (EC) No. 1907/2006 does not indicate the need to investigate further the long-term toxicity to aquatic organisms. Thus, in accordance to Annex IX, column 2 no further long-term toxicity test to fish is proposed.

Glycine is readily biodegradable; therefore it is not likely that aquatic organisms are exposed to the test substance since it will be ultimately degraded in sewage treatment plants. Glycine also has no potential to bioaccumulate. Furthermore, glycine did not show toxic effects on aquatic organisms at concentrations > 100 mg/L in acute aquatic toxicity tests. The amino acid is known to be a ubiquitous compound present mainly in protein molecules. Consequently, glycine is present in living organisms, in animal and vegetable foodstuff and in feed. Therefore, glycine is not expected to have any long-term toxic effects to aquatic organisms. This was confirmed in the toxictiy to Algae study where a NOEC ≥ 1000mg/L (the highest tested concentration) was observed. Therefore the chemical safety assessment does not indicate a need to investigate the further effects of Glycine on aquatic organisms, hence long-term toxicity testing with fish is considered as scientifically not necessary and unjustified.