Registration Dossier

Administrative data

Endpoint:
dermal absorption
Type of information:
(Q)SAR
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Justification for type of information:
QSAR prediction

Data source

Reference
Reference Type:
other: QSAR Database
Title:
Unnamed
Year:
2013
Report Date:
2013

Materials and methods

Test guideline
Guideline:
other: REACH guidance on QSARs R.6, May/July 2008
Principles of method if other than guideline:
Dermwin v2.01 (Q)SAR database report

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Absorption in different matrices:
Dermal absorption of the test substance was predicted to be low with an estimated dermal permeability coefficient (Kp) of 4.37E-006 cm/h and a dermal absoprtion rate of 3.05E-003 mg/cm²/event. The maximum flux Imax (Imax = Kp [cm/h] x water solubility [mg/cm³]) was calculated, resulting in dermal absorption of 1 µg glycine/cm²/h.

Applicant's summary and conclusion