Registration Dossier

Toxicological information

Exposure related observations in humans: other data

Administrative data

Endpoint:
exposure-related observations in humans: other data
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Observations in small group. Exposure to other substances cannot be excluded.

Data source

Referenceopen allclose all

Title:
No information
Author:
ACGIH (The American Conference of Governmental Industrial Hygienists) (2001). Furfural: Documentation of the treshold limit values and biological exposure, 5th edition. Cincinnati: ACGIH.
Title:
No information
Author:
NIOSH (National Institute for Occupational Safety and|Health) (1995). Health hazard evaluation report HETA 95-0147-2542- North American Refractories Company- Cincinnati.

Materials and methods

Type of study / information:
Type of experience: other: irritating properties in humans
Endpoint addressed:
eye irritation
respiratory irritation

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Results:
A study performed by the NIOSH in a grinding wheel plant reported a general higher incidence of eye and respiratory tract irritation which was attributed to furfural vapours which were detected at concentrations ranging from 20 -63 mg/m3. Eye irritation, manifested by itching, burning, tearing and/or redness, was reported by 11 of 15 workers. Ten workers noted frequent nasal irritation (stuffiness, dryness or soreness, and in one case, occasional bloody nasal discharge). Seven individuals reported dryness of the mouth or throat (ACGIH, 2001). NIOSH conducted a health hazard evaluation at a manufacturer of aluminium graphite tubes. Irritating effects on eyes, mouth, throat, and nose, and respiratory symptoms were reported. Eleven of the 15 (73%) time weighed average personal breathing zone furfural concentrations (range 0.3-4.2 ppm) exceeded the threshold limit value of 8 mg/m3 (2 ppm). However, the influence of other hazardous substances (respirable particles and phenol) and factors cannot be excluded, but are unknown (NIOSH, 1995). Therefore, the results are not useful for evaluation purposes of furfural.

Applicant's summary and conclusion