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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1980
Report date:
1980

Materials and methods

Principles of method if other than guideline:
Groups of 5 male Sherman rats were administered doses of 126, 252, 500, 1000, and 2000 mg/kg bw by gavage. The animals were observed for lethality, changes in general appearance and demeanor and body weight gain during a 14-day post-exposure period.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-hydroxyethyl acrylate
EC Number:
212-454-9
EC Name:
2-hydroxyethyl acrylate
Cas Number:
818-61-1
Molecular formula:
C5H8O3
IUPAC Name:
2-hydroxyethyl acrylate
Test material form:
not specified
Details on test material:
not specified

Test animals

Species:
rat
Strain:
Sherman
Sex:
male
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Fasting period before study: yes

ENVIRONMENTAL CONDITIONS
no details

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
corn oil
Details on oral exposure:
VEHICLE
- Concentration in vehicle: 10 %
Doses:
126, 252, 500, 1000, and 2000 mg/kg bw
No. of animals per sex per dose:
5
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: no data
- Other examinations performed: clinical signs, body weight
Statistics:
Weil CS (1952). Biometrics 8: 249-263

Results and discussion

Effect levels
Key result
Sex:
male
Dose descriptor:
LD50
Effect level:
540 mg/kg bw
95% CL:
>= 390 - <= 750
Mortality:
At the highest dose of 2000 mg/kg bw 5/5 rats died within 2-24 hrs after dosing. At the doses of 1000 and 500 mg/kg bw 2/5 rats died within 24 hrs after administration. At the two lower doses of 252 and 126 mg/kg bw, no mortality occurred.
Clinical signs:
other: No changes in general appearance and demeanor were observed among any of the surviving animals.

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria