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EC number: 212-454-9 | CAS number: 818-61-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- - QMRF: see 'Overall remarks, attachments'.
- QPRF: see 'Executive summary'. - Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Calculation of aqueous hydrolysis rate constant. Software used: SRC HYDROWIN v2.00
- GLP compliance:
- no
- Specific details on test material used for the study:
- - SMILES Code: O=C(OCCO)C=C
- Estimation method (if used):
- HYDROWIN v2.00 (chemical class: ESTER)
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- 9.001 yr
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: Kb half-life; The substance is not within the applicability domain of the model.
- pH:
- 8
- Temp.:
- 25 °C
- DT50:
- 328.762 d
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: Kb half-life; The substance is not within the applicability domain of the model.
- Other kinetic parameters:
- Kb at atom#2: 2.440E-002 L/mol*sec
Total Kb for pH > 8 at 25 °C : 2.440E-002 L/mol*sec - Executive summary:
QPRF: HYDROWIN v2.00
1.
Substance
See “Test material identity”
2.
General information
2.1
Date of QPRF
24 Oct. 2013
2.2
QPRF author and contact details
BASF SE, Dept. for Product Safety, Ludwigshafen, Germany
3.
Prediction
3.1
Endpoint
(OECD Principle 1)Endpoint
Aqueous hydrolysis rate
Dependent variable
Hydrolytic half-life
3.2
Algorithm
(OECD Principle 2)Model or submodel name
WSKOWWIN
Model version
v. 2.00
Reference to QMRF
Estimation of Aqueous Hydrolysis Rate Constants using HYDROWIN v2.00 (EPI Suite v4.11) (QMRF)
Predicted value (model result)
See “Results and discussion”
Input for prediction
Chemical structure via CAS number or SMILES
Descriptor values
- SMILES: structure of the compound as SMILES notation
Fragment values:
- Taft constant (sigma*)
- Steric factor (Es)
- Hammett constants (sigma-meta and sigma-para)
3.3
Applicability domain
(OECD principle 3)Domains:
1) Chemical class
An equation for the estimation of the aqueous hydrolytic rate constant is available for the chemical class of the substance.
2) Fragments (On-Line HYDROWIN User’s Guide, Appendix E)
Not all fragments were identified.
3.4
The uncertainty of the prediction
(OECD principle 4)According to REACH Guidance Document R.7a, (Nov. 2012), hydrolysis kinetics are usually determined experimentally. The guidance document also lists HYDROWIN as a means to estimate the hydrolytic half-life. The estimation is limited to only a few chemical classes. The model marks uncertainties of the estimate due to substitute values for missing fragments. As yet, the QSAR equations in HYDROWIN have not been rigorously tested with an external validation dataset. Currently, the number of chemicals with evaluated hydrolysis rates is relatively small in number, and the available data have been used to train the QSAR regressions. The training data set for esters has an acceptable size (n = 124). Equations for the other chemical classes were developed on very small databases (n = 7 to 20); therefore the reliability of estimations for members of other chemical classes than esters is low.
3.5
The chemical mechanisms according to the model underpinning the predicted result
(OECD principle 5)Hydrolysis is a common degradation route in the environment, where reaction of a substance with water with a net exchange of the X group with an OH at the reaction centre such that RX + H2O →ROH + HX. Hydrolysis is often dependent upon pH as the reaction is commonly catalysed by hydrogen or hydroxide ions.
The model uses the principle of linear free energy relationships (LFER) to estimate the aqueous hydrolysis rate.
References
- US EPA (2012). On-Line HYDROWIN User’s Guide, Appendix E: Fragment Substituent Values Used by HYDROWIN.
- ECHA (2012). REACH Guidance Document R.7a, (Nov. 2012). 381 pp.
Identified fragments for the current substance:
If the substance is an ester:
Applicable
R2 substituent is an alkyl carbon or an aromatic carbon.
yes
R1 substituent is either an alkyl carbon, an aromatic carbon or a hydrogen.
yes
Appendix E. Fragment Substituent Values Used by HYDROWIN
Fragment
Es
sigma*
sigma-meta
sigma-para
Fragment identified by HYDROWIN
Substitute fragment (warning by HYDROWIN)
Name of R group according to HYDROWIN
-CH3
-1.12
-0.49
-0.06
-0.14
yes
no
-CH2-CH2-CH2-CH3
-1.43
-0.49
-0.07
-0.16
no
yes
n-butyl
-CH=CH2
-3.19
0.07
0.08
-0.09
yes
no
-Phenyl
-3.43
0.26
0.05
-0.01
yes
yes
-Naphthyl
-3.43
0.26
0.05
-0.01
no
yes
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- the test material was not characterized in accordance with GLPs.
- Qualifier:
- according to guideline
- Guideline:
- other: TSCA guidelines, section 796.3500 Hydrolysis as a Function of pH at 25 °C.
- GLP compliance:
- yes
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): hydroxyethyl acrylate
- Analytical purity: 98.52 % - Radiolabelling:
- no
- Analytical monitoring:
- yes
- Buffers:
- Buffers : Buffered solutions were prepared at pH 3 with formic acid (0.05 M), pH 7 with potassium dihydrogen phosphate (0.05 M) and at pH 11 using Sodium bicarbonate (0.025 M).
- Details on test conditions:
- TEST METHOD
Test material was added to the buffered solutions at a concentration less than 1 mm (15 µL test material /150 mL solution). Approximate nominal concentration of HEA was 110 mg/L. The concentration of HEA was at least several orders of magnitude below the water solubility. Portions (10 mL) of the test solutions were transferred to the uniquely labeled 10 ml serum bottles and sealed with Teflon coated rubber septa and aluminum crimp seals. The test solutions were incubated in the dark at 25 ± 1°C. Periodically test solutions were removed for measurement of pH and the analysis of the test material remaining in the solution. Single test samples were removed at each time and analyzed in triplicate by reverse phase HPLC using UV detection.
For test samples at pH 11, 20 µL portions of formic acid were added prior to analysis to adjust the sample to the pH range of 5 to 6 to minimize further hydrolysis. The following sampling schedule is described in the TSCA guidelines:
- Procedure1: If 60-70% conversion occurs within 28 days, then a minimum of 6 measurements will be made at a regular intervals between 20- 70% hydrolysis
- Procedure 2: If the reaction is too slow to conveniently follow the hydrolysis to a high conversion in 28 days, but is still rapid enough to attain at least 20% conversion, the test solution should be analyzed at 15 to 20 time points at regular intervals after 10% conversion is attained.
- Procedure 3: If less than 20% conversion occurs after 28 days, then the concentration of test chemical after 28 days will be determined and a half life of > x days reported.
Methyl ether of hydroquinone (MEHQ) is routinely added to HEA during manufacture to inhibit polymerization; therefore the effect of MEHQ on the hydrolysis of HEA was evaluated. The hydrolysis rate at pH 11for 2 different samples of HEA containing different concentrations of MEHQ were determined. The first sample of HEA contained 398 ppm MEHQ and while the second sample contained 275 ppm MEHQ.
For each hydrolysis experiment, the natural logarithm of the test substance concentration was plotted as a function of time. At a constant pH, straight line was obtained indicating pseudo-first order kinetics. The slope of the regression line was equal to -Kh, where Kh was the pseudo- first order kinetics. Using the relationship, T 1/2 = ln 2/ Kh , the half life of the hydrolysis reaction was determined. The following relationship holds for hydrolysis reactions in buffered systems:
- Kh = KA [ H+] + KB [ OH- ] + KN
Where KA, KB and KN are the second order rate constants for the acid and base catalyzed and neutral water hydrolysis reaction respectively. At a given pH, this equation contains 3 unknowns, KA, KB and KN Thus three equations are required to determine three unknown values. This was accomplished by measuring the hydrolysis rate at pH 3, 7 and 11. - Duration:
- 28 d
- pH:
- 3
- Temp.:
- 25 °C
- Initial conc. measured:
- 110 mg/L
- Duration:
- 28 d
- pH:
- 7
- Temp.:
- 25 °C
- Initial conc. measured:
- 110 mg/L
- Duration:
- 5 d
- pH:
- 11
- Temp.:
- 25 °C
- Initial conc. measured:
- 110 mg/L
- Transformation products:
- not measured
- Key result
- pH:
- 3
- Temp.:
- 25 °C
- DT50:
- > 270 d
- Type:
- (pseudo-)first order (= half-life)
- Key result
- pH:
- 7
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 0 d-1
- DT50:
- > 270 d
- Type:
- (pseudo-)first order (= half-life)
- Key result
- pH:
- 11
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 13.72 d-1
- DT50:
- 0.05 d
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: r2 = 0.9994
- Details on results:
- HEA hydrolyzed rapidly at pH 11, with a half life of 0.051 days. In contrast slow hydrolysis was observed at pH 3 and pH 7, with the half lives greater than 230 days. These results were explained by the presence of ester functional groups in HEA which are more susceptible to hydrolysis at higher pH. Based on the hydrolysis rate constant determined for HEA, half lives of 35 to 40 days would be expected at pH 8.
- Effect of MEHQ inhibitor on hydrolysis: Samples of HEA containing 398 and 275 ppm MEHQ had half lives of 1.34 and 1.30 hours respectively. Thus a 45% higher concentration of MEHQ resulted in only a 3% longer half life. These results indicate that varying the MEHQ levels from 275 to 398 ppm in HEA had minimal effect on the rate of hydrolysis at pH 11. This observation was consistent with the fact that the MEHQ was diluted 10,000 fold in the test solutions, thereby minimizing any possible effect on the hydrolysis reaction. - Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1996 -1997
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- test material characterization was not audited for compliance with GLP
- Principles of method if other than guideline:
- In an initial experiment (Experiment A, 28 day duration), the hydrolysis rate for HEA was determined in synthetic seawater at 25 °C. Based on the results of this experiment, a second study was set (Experiment B, 70 to 91 day duration) to determine the hydrolysis rates for HEA at 5, 12, and 25°C in synthetic seawater buffered to pH 8.1.
- GLP compliance:
- yes
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): hydroxyethyl acrylate (HEA)
- Analytical purity: 98.52 % - Analytical monitoring:
- yes
- Buffers:
- - pH for experiment A: 8.15
- pH for experiment B: 8.1
- Composition of buffer: For Experiment B buffered seawater was prepared by dissolving 40 g instant ocean and 3.1 g boric acid in 1 L water. The pHof the solution was adjusted from 6.8 to 8.1 with 1M NaOH and sterilized. - Details on test conditions:
- TEST MEDIUM
- Test medium: Synthetic sea water
METHOD
In an initial experiment (Experiment A, 28 days duration), the hydrolysis rate for HEA was determined in synthetic sea water at 25 °C. Based on the results of this experiment , a second study was set (Experiment B, 70 to 91 days duration) to determine hydrolysis rate at 5, 12 and 25°C in synthetic sea water buffered to pH 8.1
- Experiment A: Synthetic sea water was prepared by dissolving 40 gm of instant ocean in water and diluting to 1L. The solution was then sterilized. A 15 µL portion of HEA was added to 150 ml of synthetic sea water to obtain a final approximate nominal concentration of 110 mg/L. The pH of the test solution was 8.15. Portions (10 mL) of the test solutions were transferred to uniquely labeled 10 mL serum bottles and sealed with unique Teflon coated rubber septa and aluminum crimp seals. The test solutions were incubated in thedark for 28 days at 25 ± 1 °C. Duplicate samples were removed for the measurement of pH and analyses of HEA remaining in the solution after 0, 5, 14, 21 and 28 days. Each test solution was analyzed in triplicate by reverse phase HPLC using UV detection.
- Experiment B: Test solutions were prepared in the same manner as described above, except that the sea water was buffered to pH 8.1 with boric acid to minimize changes in pH. Buffered sea water was prepared by dissolving 40 gm instant ocean and 3.1 gm boric acid in water and diluting to 1 L. The pH of the solution was adjusted from 6.8 to 8.1 with 1 N NaOH and sterilized. HEA was added to obtain a final approximate nominal concentration of 110 mg/L. Test solutions were incubated in the dark for up to 91 days at 21 ± 1°C, 12 ± 1°C and 5 ± 1°C. Duplicate test solutions were removed for the measurement of ph and the analysis of HEA remaining in the solution after 0, 7, 28, 42, 56, 70 and 91 days. The experiment at 12 °C was terminated after day 70 because of a faulty water bath. Each test solution was analyzed in triplicate by reverse phase HPLC.
For each hydrolysis experiment the natural logarithm of the test substance concentration was plotted as a function of time. At a constant pH, a straight line was obtained indicating pseudo-first order kinetics. The slope of the linear regression line was equal to –Kh where Kh was the pseudo- first order hydrolysis rate constant. Using the relationship, T 1/2 = ln 2/ Kh , the half life of the hydrolysis reaction was determined.
The temperature dependence of hydrolysis reactions were determined by using Arrhenius equation: y = Ae –E/ RK - Duration:
- 28 d
- pH:
- 8.15
- Temp.:
- 25 °C
- Initial conc. measured:
- 110 mg/L
- Duration:
- 91 d
- pH:
- 8.1
- Temp.:
- 25 °C
- Initial conc. measured:
- 110 mg/L
- Duration:
- 70 d
- pH:
- 8.1
- Temp.:
- 12 °C
- Initial conc. measured:
- 110 mg/L
- Duration:
- 91 d
- pH:
- 8.1
- Temp.:
- 5 °C
- Initial conc. measured:
- 110 mg/L
- Number of replicates:
- Each test solution was analyzed in triplicate.
- Preliminary study:
- After 28 days, the concentration of HEA was reduced by 40%. However, the kinetics of hydrolysis were not pseudo-first order as indicated by a decrease in the slope of the line over time (non-linear plot). This was likely due to a decrease in pH of the test solutions from pH 8.15 to 7.85 over the 28-day experiment.
- Transformation products:
- not measured
- pH:
- 8.1
- Temp.:
- 5 °C
- Hydrolysis rate constant:
- 0 d-1
- DT50:
- 290 d
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: r² = 0.8255
- pH:
- 8.1
- Temp.:
- 12 °C
- Hydrolysis rate constant:
- 0.01 d-1
- DT50:
- 100 d
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: r² = 0.9527
- pH:
- 8.1
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 0.04 d-1
- DT50:
- 17 d
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: r² = 0.9982
- Details on results:
- For an overview of the test results, see 'Any other information on results incl. tables'. The 17-day half-life at 25 °C determined in Exp. B suggests that the hydrolysis rate of HEA was accelerated by the synthetic seawater. Investigations into whether borate buffer accelerated the reaction showed that borate buffer did not affect the rate of reaction. Pseudo-first order kinetics were observed, with measured half-lives of 290 days at 5 °C, 100 days at 12 °C, and 17 days at 25 °C. Based on rate constants determined in a previous study which did use seawater, a hydrolysis half-life of 29 days in "regular" water would have been expected at 25 °C (pH 8.1). Thus, seawater appeared to accelerate the rate of HEA hydrolysis.
Referenceopen allclose all
Tables: Hydrolysis of HEA in buffered solutions at 25 °C
Results for hydrolysis studies for HEA:
aPseudo- first order rate constant determined at indicated pH
Calculated KA,KBand KN, second order rate constants:
|
The results for the hydrolysis of HEA in buffered synthetic sea water at 5, 12 and 25°C are:
Temperature ( °C ) |
Rate constant (days-1)a |
Half life (days) |
r2 b |
5 |
0.0024 |
290 |
0.8255 |
12 |
0.0068 |
100 |
0.9527 |
25 |
0.0399 |
17 |
0.9982 |
apseudo first order rate constant;bcorrelation coefficient
The results for the hydrolysis of HEA in non buffered synthetic sea water at 25°C (Experiment A) were:
Day |
pH |
HEA (mg/L) |
Std deviation |
RSD |
ln (mg/L) |
0 |
8.15 |
108.6 |
0.20 |
0.19 % |
4.688 |
5 |
8.05 |
91.0 |
0.17 |
0.18 % |
4.511 |
5 |
8.04 |
90.7 |
0.16 |
0.18 % |
4.508 |
14 |
7.86 |
77.6 |
0.12 |
0.15 % |
4.352 |
14 |
7.85 |
79.4 |
4.08 |
5.14 % |
4.374 |
21 |
7.86 |
68.6 |
0.11 |
0.16 % |
4.228 |
21 |
7.88 |
67.8 |
0.13 |
0.19 % |
4.217 |
28 |
7.84 |
65.6 |
0.06 |
0.10 % |
4.184 |
28 |
7.86 |
65.5 |
0.49 |
0.75 % |
4.183 |
After 28 days, the concentration of HEA was reduced by 40% and the kinetics of hydrolysis was not pseudo- first order as indicated by a decrease in the slope of the line over time. This was likely due to a decrease in pH of the test solutions from pH .15 to 7.85 over the 28 day experiment.
The results for the hydrolysis of HEA in buffered synthetic sea water at 5°C (Experiment B) were:
Day |
HEA (mg/L) |
Std deviation |
RSD |
ln (mg/L) |
0 0 |
106.7 106.3 |
0.08 0.49 |
0.07 % 0.46 % |
4.670 4.667 |
7 7 |
109.8 107.8 |
3.38 0.08 |
3.08 % 0.07 % |
4.699 4.680 |
28 28 |
102.3 102.3 |
0.13 0.06 |
0.13 % 0.06 % |
4.628 4.628 |
42 42 |
100.7 100.6 |
0.20 0.09 |
0.20 % 0.09 % |
4.613 4.611 |
56 56 |
97.9 98.7 |
0.25 0.23 |
0.26 % 0.23 % |
4.584 4.592 |
70 70 |
85.7 85.6 |
0.11 0.03 |
0.13 % 0.04 % |
4.451 4.449 |
91 91 |
90.0 89.1 |
0.23 0.19 |
0.26 % 0.21 % |
4.500 4.490 |
The results for the hydrolysis of HEA in buffered synthetic sea water at 12 °C (Experiment B) were:
Day |
HEA (mg/L) |
Std deviation |
RSD |
ln (mg/L) |
0 0 |
106.7 106.3 |
0.08 0.49 |
0.07 % 0.46 % |
4.670 4.667 |
7 7 |
109.5 104.1 |
8.85 0.14 |
8.08 % 0.13 % |
4.696 4.645 |
28 28 |
92.4 91.3 |
1.10 0.06 |
1.19 % 0.07 % |
4.526 4.514 |
42 42 |
85.3 85.2 |
0.03 0.08 |
0.04 % 0.10 % |
4.446 4.445 |
56 56 |
79.4 79.3 |
0.05 0.05 |
0.06 % 0.06 % |
4.375 4.473 |
70 70 |
64.9 64.9 |
0.13 0.13 |
0.20 % 0.20 % |
4.173 4.172 |
The results for the hydrolysis of HEA in buffered synthetic sea water at 25°C (Experiment B) were:
Day |
HEA (mg/L) |
Std deviation |
RSD |
ln (mg/L) |
0 0 |
106.7 106.3 |
0.08 0.49 |
0.07 % 0.46 % |
4.670 4.667 |
7 7 |
82.1 82.5 |
0.11 0.05 |
0.13 % 0.06 % |
4.408 4.413 |
28 28 |
37.8 36.9 |
0.06 0.04 |
0.16 % 0.12 % |
3.631 3.608 |
42 42 |
20.5 21.6 |
0.03 0.05 |
0.17 % 0.24 % |
3.023 3.070 |
56 56 |
12.6 12.5 |
0.03 0.01 |
0.20 % 0.04 % |
2.536 2.528 |
70 70 |
6.0 6.2 |
0.25 0.01 |
4.15 % 0.20 % |
1.789 1.818 |
91 91 |
3.0 2.9 |
0.06 0.06 |
1.95 % 2.01 % |
1.094 1.071 |
Description of key information
In contact with water at neutral pH no hydrolysis of 2-hydroxyethyl acrylate will be observed. In alkaline water, the substance will hydrolyse rapidly.
Key value for chemical safety assessment
Additional information
QSAR-disclaimer
In Article 13 of Regulation (EC) No 1907/2006, it is laid down that information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI (of the same Regulation) are met. Furthermore according to Article 25 of the same Regulation testing on vertebrate animals shall be undertaken only as a last resort.
According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific validity of the (Q)SAR model has been established, (2) the substance falls within the applicability domain of the (Q)SAR model, (3) the results are adequate for the purpose of classification and labeling and/or risk assessment and (4) adequate and reliable documentation of the applied method is provided.
For the assessment of 2-hydroxyethyl acrylate (Q)SAR results were used for hydrolysis.The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are considered to be not entirely adequately fulfilled, as unidentified fragments were identified. Nevertheless, the QSAR data provides an indication of the hydrolysis rate.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
