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EC number: 212-454-9 | CAS number: 818-61-1
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Sensitization to patch test acrylates.
- Author:
- Kanerva L et al.
- Year:
- 1 988
- Bibliographic source:
- Contact Dermatitis 18: 10-15
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- case report
- Principles of method if other than guideline:
- Data on allergic contact dermatitis from acrylates and 4 patients sensitized during routine patch testing were reported in the publication.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-hydroxyethyl acrylate
- EC Number:
- 212-454-9
- EC Name:
- 2-hydroxyethyl acrylate
- Cas Number:
- 818-61-1
- Molecular formula:
- C5H8O3
- IUPAC Name:
- 2-hydroxyethyl acrylate
- Test material form:
- not specified
- Details on test material:
- not specified
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 2-Hydroxyethyl acrylate
Method
- Type of population:
- general
- Ethical approval:
- not specified
- Subjects:
- no data
- Clinical history:
- no data
- Controls:
- no controls
- Route of administration:
- dermal
- Details on study design:
- Type of test used: patch test (epicutaneous test)
Administration:
- Type of application: occlusive (Finn chamber method)
- Description of patch: The tests are applied on the back with a non-occlusive porous tape (Scanpor© Surgical Tape, Norgeplaster A/S, Norway) or on the thighs and then closed by a Finn chamber.
- Vehicle / solvent: petrolatum
- Concentrations: 0.5 % (w/w)
- Testing/scoring schedule: The tests are read on removal and 24 h, 48 h, and 96-120 after removal (at least 3 readings).
- Removal of test substance: after 24 h
Examinations: All readings are made by a dermatologist.
Results and discussion
- Results of examinations:
- Observations during 1985-1986:
- Number of subjects with positive reactions: 3/24 (diagnosed as having an occupational allergic contact dermatitis to acrylates)
- Number of subjects with negative reactions 12/24
- Number of subjects with irritating reactions 9/24 (3 of these were actively sensitized to 2-HEA among other acrylates)
Applicant's summary and conclusion
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