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EC number: 204-884-0
CAS number: 128-39-2
of oral toxicokinetics based on the phys-chem of 2,6 DTBPindicates
that the substance is lipophilic and can diffuse across the lipid domain
of cellular membranes.
absorption in the GI tract is expected to occur predominantly via simple
diffusion. The mean predicted fractional absorption of 2,6 DTBP in the
human is 0.89 (Simcyp v.10.0). Significant
first pass effects are not expected for 2,6 DTBP. From the results of
the 28-day repeat dose toxicity study in rats there is evidence of
systemic exposure to 2,6 DTBP following oral gavage dosing: histopathological
examination of the tissues at the end of the study identified changes in
the liver in animals dosed at 600 mg/kg body weight/day.Additional
evidence of systemic exposure was noted in a preliminary reproduction
screening toxicity test study in rats exposed to 2,6 DTBP by oral gavage
dosing for between 4 and 6 weeks: animals dosed at 750 mg/kg body
weight/day showed severe reactions to treatment with sedation, ataxia,
recumbancy, tremors and spasms. Following
systemic exposure to 2,6 DTBP in the circulation, a rapid metabolism via
glucuronisation and sulphatation may be predicted from the chemical
structure with excretion mainly via the kidney. The information for a
chemically similar compound would imply a short half life for 2,6 DTBP
at the very low level of potential human exposure with no likelihood for
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