Registration Dossier
Registration Dossier
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EC number: 218-760-9 | CAS number: 2226-96-2
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 0.03 mg/L
- Assessment factor:
- 50
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 0.54 mg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 0.003 mg/L
- Assessment factor:
- 500
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 430 mg/L
- Assessment factor:
- 1
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 0.126 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 0.017 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 0.031 mg/kg soil dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential for bioaccumulation
Additional information
Conclusion on classification
Acute toxicity:
Invertebrates are the most sensitive species to the toxic effects of 4-OH TEMPO with an acute EC50 of 54 mg/L. Based on the results obtained in the aquatic toxicity studies, 4-OH TEMPO is not classified with respect to acute toxicity to the environment according to Directive 67/548/EEC (DSD) and Regulation (EC) No 1272/2008 (CLP/GHS).
Chronic toxicity:
Invertebrates are the most sensitive species to the toxic effects of 4-OH TEMPO with an acute EC50 of 54 mg/L and a NOEC of 1.5 mg/L derived from a daphnia reproduction study. Classification is based on the chronic daphnia study. Based on these results, the substance does not require classification for environmental chronic toxicity according to Directive 67/548/EEC (DSD) and Regulation (EC) No 1272/2008 (CLP/GHS).
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