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Registration Dossier
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EC number: 218-760-9 | CAS number: 2226-96-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
4-Hydroxy TEMPO was tested for short-term toxicity to fish in a 96 h-semistatic test according to EU-method C.1 and OECD guideline 203. A LC50 of 545 mg/L was assessed.
4-Hydroxy TEMPO was tested for acute toxicity to aquatic freshwater invertebrates in a 48 h-static test according to EU-method C.2 and OECD guideline 202. The EC50 was assessed at 54 mg/L.
4-Hydroxy TEMPO was tested for reproductive toxicity to Daphnia in a 21 day semistatic test according to OECD guideline 202 Part II which was in accordance to the EU draft method C.20. The NOEC was determined at 1.5 mg/L and the LOEC at 4.5 mg/L.
4-Hydroxy TEMPO was tested for toxicity to algae in a 72 h-static test according to EU-method C.3 and OECD guideline 201. The EC50 based on growth rate was assessed at 1038 mg/L. The overall NOEC was determined at 22 mg/L.
4-Hydroxy TEMPO was tested for toxicity to microorganisms in a 16 hours toxicity to Pseudomonas putida test according to DIN 38412. An EC50 of 890 mg/L and an EC10 of 430 mg/L was assessed.
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