4-hydroxy-2,2,6,6-tetramethylpiperidinoxyl

Specific investigations: other studies

Administrative data

Endpoint:

biochemical or cellular interactions

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Original reference not available

Data source

Reference

Reference Type:

publication

Title:

Neurophysiological consequences of nitroxide antioxidants

Author:

Hahn, S.M., Lepinski, D.L., DeLuca A.M., Mitchell J.B., Pellmar, T.C.

Year:

1995

Bibliographic source:

Can. J. Physiol. Pharmacol. 73, 399-403

Materials and methods

Test material

Test material information

Constituent 1

Reference substance name:

4-hydroxy-2,2,6,6-tetramethylpiperidinoxyl

EC Number:

218-760-9

EC Name:

4-hydroxy-2,2,6,6-tetramethylpiperidinoxyl

Cas Number:

2226-96-2

Molecular formula:

C9H18NO2•

IUPAC Name:

1-λ1-Oxidanyl-2,2,6,6-tetramethylpiperidin-4-ol

Results and discussion

Any other information on results incl. tables

4-Hydroxy-TEMPO showed a smaller effect than TEMPO or Tempamine. 1 mM caused a small but significant enhancement of E/S coupling (relationship between PSP and population spike) and synaptic efficacy, at 5 Mmol a greater potentiation of E/S coupling was observed, but the synaptic potential was not altered. The effects were reversible. At the high concentration additionally in 3 of 5 slices a secondary population spike was developed by the somatic field potential, suggesting some hyperexcitability.