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Toxicological information

Specific investigations: other studies

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Administrative data

Endpoint:
biochemical or cellular interactions
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Original reference not available

Data source

Reference
Reference Type:
publication
Title:
Neurophysiological consequences of nitroxide antioxidants
Author:
Hahn, S.M., Lepinski, D.L., DeLuca A.M., Mitchell J.B., Pellmar, T.C.
Year:
1995
Bibliographic source:
Can. J. Physiol. Pharmacol. 73, 399-403

Materials and methods

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Any other information on results incl. tables

4-Hydroxy-TEMPO showed a smaller effect than TEMPO or Tempamine. 1 mM caused a small but significant enhancement of E/S coupling (relationship between PSP and population spike) and synaptic efficacy, at 5 Mmol a greater potentiation of E/S coupling was observed, but the synaptic potential was not altered. The effects were reversible. At the high concentration additionally in 3 of 5 slices a secondary population spike was developed by the somatic field potential, suggesting some hyperexcitability.

Applicant's summary and conclusion