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Physical & Chemical properties

Water solubility

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Description of key information

The water solubility of 4-Hydroxy-TEMPO was determined to be 629.3 g/L using the flask method. Thus, the test item is considered to be very soluble in water.

Key value for chemical safety assessment

Water solubility:
629.3 g/L
at the temperature of:
20 °C

Additional information

A study was conducted according to OECD TG 105, Regulation (EC) No 440/2008 method A.5 and OPPTS 830.7840 using the flask method. Therefore double distilled water was added dropwise to three individual sample weights of the test item (9.13 mg, 5.09 mg and 14.42 mg) until a two phase mixture (liquid/solid) appeared. These mixtures are stirred at 30°C for different time intervals (24, 48 and 72h). After equilibration at test temperature (approximately 4 days at 20°C) aliquots of the saturated aqueous phases were taken to prepare two individual dilutions for each flask. The concentrations of the test item were determined by HPLC analysis. The water solubility of 4-Hydroxy-TEMPO was determined to be 629.3 g/L at 20°C. Thus, the test item is considered to be very soluble in water.