Registration Dossier
Registration Dossier
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EC number: 203-652-6 | CAS number: 109-16-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- Article in Russian. Only abstract in English.
Data source
Reference
- Reference Type:
- publication
- Title:
- ГИГИЕНИЧЕСКОЕ ОБосновАНИЕ ПРЕДЕЛЬНО ДОПУСТИМОЙ КОНЦЕНТРАЦИИ ТРИЭТИЛЕНГЛИКОЛЬДИМЕТАКРИЛАТА В ВОДЕ ВОДОЕМОВ (Hygienic justification of maximum permitted concentrations of TREGDMA in water reservoirs)
- Author:
- Manenko AK et al.
- Year:
- 1 982
- Bibliographic source:
- Gigiena i Sanitarija, 47(4), 1982
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- no data on guideline available
- GLP compliance:
- no
- Test type:
- other: no data on testing procedure
Test material
- Reference substance name:
- 2,2'-ethylenedioxydiethyl dimethacrylate
- EC Number:
- 203-652-6
- EC Name:
- 2,2'-ethylenedioxydiethyl dimethacrylate
- Cas Number:
- 109-16-0
- Molecular formula:
- C14H22O6
- IUPAC Name:
- ethane-1,2-diylbis(oxyethane-2,1-diyl) bis(2-methylacrylate)
- Details on test material:
- Purity not specified, but commercial grade assumed.
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): ТРИЭТИЛЕНГЛИКОЛЬДИМЕТАКРИЛАТ (Trietilenglikoldimetacrilat), TGM-3
- Physical state: liquid
- Analytical purity: no data
- Impurities (identity and concentrations): technical TGM-3: 3,5% Toluene, 0,071% Hydroquinone; treated TGM-3: 0,0043% Hydroquinone
- Purity test date: no data
- Lot/batch No.: no data
- Expiration date of the lot/batch: no data
- Stability under test conditions: no data
- Storage condition of test material: no data
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Doses:
- no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 10 750 mg/kg bw
- Based on:
- not specified
- Remarks on result:
- other: mice
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Conclusions:
- The acute oral LD50 of TREGDMA is reported to be 10750 mg/kg bw in mice.
- Executive summary:
The acute oral LD50 of TREGDMA is reported to be 10750 mg/kg bw in mice.
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