Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Exposure related observations in humans: other data

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Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
2002

Materials and methods

Type of study / information:
Type of experience: other: human - skin sensitization, case reports

Test material

Constituent 1
Chemical structure
Reference substance name:
2,2'-ethylenedioxydiethyl dimethacrylate
EC Number:
203-652-6
EC Name:
2,2'-ethylenedioxydiethyl dimethacrylate
Cas Number:
109-16-0
Molecular formula:
C14H22O6
IUPAC Name:
ethane-1,2-diylbis(oxyethane-2,1-diyl) bis(2-methylacrylate)
Details on test material:
Purity not specified, but commercial grade assumed.

Results and discussion

Any other information on results incl. tables

Results:
Allergic contact dermatitis was diagnosed from the positive results of patch 

tests and type I allergy to latex and common environmental allergens from the 

positive results of prick tests. It was found that the dental personnel was 

hypersensitive primarily to components of disinfectants, metals, rubber and 

fragrances. Acrylates caused allergy only in the dentists (20-25% of all examd. 

patients). Among 20  acrylate-sensitive dentists, 12 reacted to 

Triethyleneglycol dimethacrylate (test concentration: 2.0 % in petrolatum).

Applicant's summary and conclusion