Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
dermal absorption
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2013

Materials and methods

Principles of method if other than guideline:
The physico chemical parameters of MW, Log P and saturated aqueous solubility have been used in the evaluation of 56 methacrylate compounds. An output of predicted steady-state flux was calculated using the principles defined in the Potts and Guy prediction model. (Potts RO and Guy RH (1992). Predicting Skin Permeability. Pharm. Res. 9(5): 663- 669)
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2,2'-ethylenedioxydiethyl dimethacrylate
EC Number:
203-652-6
EC Name:
2,2'-ethylenedioxydiethyl dimethacrylate
Cas Number:
109-16-0
Molecular formula:
C14H22O6
IUPAC Name:
ethane-1,2-diylbis(oxyethane-2,1-diyl) bis(2-methylacrylate)
Test material form:
liquid
Specific details on test material used for the study:
- Name of test material (as cited in study report): Triethyleneglycol dimethacrylate

Test animals

Details on test animals or test system and environmental conditions:
not applicable; in silico modelling

Administration / exposure

Type of coverage:
other: not applicable; in silico modelling
No. of animals per group:
not applicable; in silico modelling

Results and discussion

Absorption in different matrices:
predicted flux 4.989 μg/cm²/h; the relative dermal absorption is low

Any other information on results incl. tables

Based on a molecular weight of 286.32 g/mol and a log Kow of 2.3, the predicted flux of TREGDMA is 4.989 μg/cm²/h; the relative dermal absorption is low.

Applicant's summary and conclusion

Conclusions:
The dermal absorption of TREGDMA is predicted to be low; the predicted flux is 4.989 μg/cm²/h.
Executive summary:

The dermal absorption (steady-state flux) of TREGDMA has been estimated by calculation using the principles defined in the Potts and Guy prediction model.

Based on a molecular weight of 286.32 g/mol and a log Kow of 2.3, the predicted flux of TREGDMA is 4.989 μg/cm²/h; the relative dermal absorption is low.