Acrylic acid, monoester with propane-1,2-diol

Sensitisation data (human)

Administrative data

Endpoint:

sensitisation data (humans)

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Well documented, acceptable publication

Data source

Reference

Reference Type:

publication

Title:

Allergic Contact Dermatitis in Dentists and Dental Nurses.

Author:

Kiec-Swierczyniska M, Krecisz B

Year:

2002

Bibliographic source:

Exog. Dermatol. 1: 27-31

Materials and methods

Type of sensitisation studied:

skin

Study type:

survey

Principles of method if other than guideline:

The incidence of allergic contact dermatitis was analysed in 79 dentists and 46 dental nurses referred during 1990 - 2000 for consultation to the Nofer Institute of Occupational Medicine, Lodz, Poland. Allergic contact dermatitis was diagnosed from the positive results of patch tests and type I allergy to latex and common environmental allergens from the positive results of prick tests.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

2-hydroxypropyl acrylate

EC Number:

213-663-8

EC Name:

2-hydroxypropyl acrylate

Cas Number:

999-61-1

Molecular formula:

C6H10O3

IUPAC Name:

2-hydroxypropyl acrylate

Method

Type of population:

occupational

Ethical approval:

not specified

Subjects:

- Number of subjects exposed: 125 (79 dentists and 46 dental nurses)
- Sex: 72 women and 7 men (dendists) and 46 women (dental nurses)

Controls:

none

Route of administration:

dermal

Details on study design:

Type of test used: patch test (epicutaneous test)

Administration: Patch tests were applied and inspected according to the guidelines of the International Contact Dermatitis Research Group (Fregert S: Manual of Contact Dermatitis, ed 2., Copenhagen, Munksgaard, 1981).

Results and discussion

Results of examinations:

- Contact dermatitis (at least 1 positive result of the patch test) was diagnosed in 56 (70.9 %) dentists and 34 (73.9 %) dental nurses. Among the most frequent sensitizers were acrylates with 25.3 %. Allergy to acrylates was detected in 20 dentists of which 8 reacted to 2-hydroxyethyl acrylate and 5 to 2-hydroxypropyl acrylate, respectively.
- Number of subjects with positive reactions: 5/20