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EC number: 247-118-0 | CAS number: 25584-83-2
Hydroxypropyl acrylate is corrosive to skin and eyes. Hydroxypropyl acrylate may be irritating to the respiratory tract.
Exposure: 1 hour
Mean erythema and edema score:
mean 24 – 48 h
*: extending beyond the area of application
ss: severe desquamation
Exposure: 4 hours
ns: soft necrosis
np: parchment-like necrosis, anemic
n: necrosis, anemic
Mean scores after 24, and 48 h*:
*72 hrs-scores were missing in the raw data.
** Nictitating membrane white
Findings at test termination:
loss of corneal tissue
Several studies demonstrated that undiluted hydroxypropyl acrylate is severely irritating or corrosive to skin. The key study is summarized below.
Undiluted hydroxypropyl acrylate was applied to the skin of New Zealand White rabbits with an occlusive covering for one and four hours, respectively (BASF AG 1980). Skin readings were performed after removal of the test patch and then daily on workdays until the end of the observation period (8 days) and skin reactions were scored according to the Draize scoring system. After the 4-hour application full-thickness necrosis was observed in both treated animals at test termination. Erythema scores for the time period 24-48 hrs in the two animals were 2.5 and 3.5, respectively, and edema scores for the same skin readings were 3.0 and 3.0, respectively. After the 1-hour application erythema scores (24-48 hrs ) were 1.5 and 2, respectively, and edema scores were also 1.5 and 2, respectively. Erythema was not completely reversible until test termination, and at the end of the observation period desquamation was observed on both animals.
Taking together the results of both studies, it is concluded, that the test substance is corrosive (cat. 1C).
Several studies have shown that undiluted hydroxypropyl acrylate is severely irritating and can cause serious damage to the eye. The two most reliable studies are summarized below.
Undiluted hydroxypropyl acrylate (0.05 mL) was instilled into one eye of two rabbits. The adjacent eyes were treated with saline and served as control. The eyes were not washed out after 24 hours as specified in OECD Guideline 405. Mean scores for cornea, iris, conjunctivae and chemosis (24-48 hours) were 1.75, 0.25, 2.25, and 2.0, respectively. After 8 days the cornea showed severe opacity (mean score 3.0), and in one animal loss of corneal tissue was diagnosed. In addition, slight iritis (mean score 1) and moderate lesions of the conjunctivae were noticeable (mean score 2) (BASF AG, 1974).
In another study HPA was investigated in a Draize test in New Zealand Albino rabbits. In general the techniques of tests as published by the FDA of the United States (1963) and Draize and Kelley (1952) were followed. The undiluted substance (0.1 mL) was instilled into the conjunctival sac of one eye in two rabbits (BASF AG 1978). The eyes were not washed out and examined at one hour, 24, 48, 72 hours and 7 days after instillation of the test material. During the first day after instillation the eyes showed slight or moderate corneal damage, slight iritis and severe lesions of the conjunctivae. In the course of the seven-day observation period the degree of the ocular lesions remained unchanged or decreased very slightly. Mean scores (24-48-72 hrs) for cornea, iris, conjunctivae and chemosis were 1.85, 1.0, 2.0, and 3.5. After seven days the following ocular lesions were observed: moderate opacity of the cornea, slight iritis and moderate to severe conjunctivitis. Undiluted hydroxypropyl acrylate caused severe irritation with corneal injury when instilled directly into the eyes of laboratory rabbits. Thus, based on the presented experimental evidence, HPA was assessed to have the potential to cause serious eye damage.
- FDA of the United States, Fed. Reg. 28 (119), 5582, 1963
- Draize and Kelley, Drug Cosmet. Industr. 71: 36, 1952
There exists no standard test method for the assessment of respiratory irritation. There is some evidence from several inhalation hazard tests that hydroxypropyl acrylate vapours may be irritating to the nose and respiratory tract of rats (BASF AG 1974, Union Carbide Corporation 1971). This assessment is confirmed by data on the structural analogue 2-hydroxyethyl acrylate. Since the substance is classified as corrosive, the potential to cause respiratory tract irritation is implicitly covered.
Effects on skin irritation/corrosion: corrosive Effects on eye irritation: corrosive
Based on the available data, the substance has to be classified as Skin and Eye Corr. 1B: H314: Causes severe skin burns and eye damage according to EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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