Registration Dossier
Registration Dossier
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EC number: 701-427-1 | CAS number: -
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
Modified Small Vinyl Ester induced not more than 22% growth rate inhibition in Pseudokirchneriella subcapitata at the water solubility limit. Hence, the 72h-ERC50 was above the water solubility limit, i.e. > 0.42 mg/L for bisGMA and > 38 mg/L for monomaleic adduct of bisGMA.
The NOEC based on growth rate is 10 mg/L. The concentration of bisGMA at 10 mg/L Modified Small Vinyl Ester is above its’ water solubility limit of 0.42 mg/L. The analytical TWA concentration of Monomaleic acid of bisGMA at a nominal Modified Small Vinyl Ester concentration of 10 mg/L is 1.2 mg/L (18% of 6.7 mg/L which is the TWA concentration Modified Small Vinyl Ester at 10 mg/L).
Key value for chemical safety assessment
Additional information
A guideline study of fresh water algal growth inhibition using Pseudokirchneriella subcapitata was performed with Modified Small Vinyl Ester. Algal cultures were exposed to the Water Accommodated Fractions (WAFs) prepared at loading rates of 1.0, 3.2, 10, 32 and 100 mg/L for 72 hours. Modified Small Vinyl Ester induced not more than 22% growth rate inhibition in Pseudokirchneriella subcapitata at the water solubility limit. Hence, 72h-ERC50 was above the water solubility limit, i.e. > 0.42 mg/L for bisGMA and > 38 mg/L for Monomaleic adduct of bisGMA.
The NOEC based on growth rate is 10 mg/L. The concentration of bisGMA at 10 mg/L Modified Small Vinyl Ester is above its’ water solubility limit of 0.42 mg/L. The analytical TWA concentration of Monomaleic acid of bisGMA at a nominal Modified Small Vinyl Ester concentration of 10 mg/L is 1.2 mg/L (18% of 6.7 mg/L which is the TWA concentration Modified Small Vinyl Ester at 10 mg/L).
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