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Physical & Chemical properties

Dissociation constant

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Description of key information

Results of a guideline study with no deviations and complies with GLP is used for the evaluation. Due to the chemical characteristics of the substance not a single value could be calculated, instead the pKa values for acidic and basic groups in the molecular structure of BisGMa and mono maleic adduct of BisGMA were calculated using the Perrin calculation method. The calculated pKa values was 2.5; 4.4-5.5 (4 values); and 13.0-13.6 (3 values).

Key value for chemical safety assessment

pKa at 20°C:
2.5

Additional information

Due to the chemical characteristics of the substance not a single value could be calculated, instead the following pKa values for acidic and basic groups in the molecular structure of BisGMa and mono maleic adduct of BisGMA were calculated using the Perrin calculation method.

 

 

Acidic

Basic

 

BisGMA

RRCHOH

RRCHOH

pKa

pKa

13.0

13.6

C6H5OR

C6H5OR

pKa -4.9

pKa -5.5

 

Mono maleic adduct of

BisGMA

RCOOH

CH=CHCOOH

RRCHOH

pKa

pKa

pKa

2.5

4.4

13.3

C6H5OR

pKa -4.5