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Dissociation constant

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Key value for chemical safety assessment

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In a potentiometric titration study the pKa of Chlorhexidine base was determined to be 10.78.

A model calculation resulted in pKa values of 11.41, 12.02, 2 -4 and <0 . The calculated values clearly indicate an complete dissociation in aqueous solutions in the ecological interesting pH range. Thus, the undissociated form of Chlorhexidine only exists at high pH values.